Results 61 to 70 of about 5,296 (150)

Time to Train: The Involvement of the Molecular Clock in Exercise Adaptation of Skeletal Muscle

Frontiers in Physiology, 2022
Circadian rhythms regulate a host of physiological processes in a time-dependent manner to maintain homeostasis in response to various environmental stimuli like day and night cycles, food intake, and physical activity.
Shivani Mansingh, Christoph Handschin
doaj   +1 more source

Systematic Comparison of High‐Fat Diet– and Streptozotocin‐Induced Prediabetic Obese C57BL/6J Mouse Models: A Sex‐Based Protocol Optimization Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Animal models of prediabetes (Pre‐DM) are essential for studying metabolic disease and testing therapies, yet high‐fat diet (HFD) and HFD‐plus‐streptozotocin (STZ) protocols vary in feeding duration, STZ dose, and diagnostic criteria and rarely account for sex.
Min Xu, Chao Ke, Yangkun Liu, Wenying Shi, Yang Cao, Zhengyu Li, Yi Xiao, Wei Zhang   +7 more
wiley   +1 more source

Rev-erb-α: an integrator of circadian rhythms and metabolism

Journal of Applied Physiology, 2009
The endogenous circadian clock ensures daily rhythms in diverse behavioral and physiological processes, including locomotor activity and sleep/wake cycles, but also food intake patterns. Circadian rhythms are generated by an internal clock system, which synchronizes these daily variations to the day/night alternance. In addition, circadian oscillations
Duez, Hélène, Staels, Bart
openaire   +4 more sources

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence [PDF]

Nature, 2018
The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation of the circadian machinery may be an
Sulli, Gabriele, Rommel, Amy, Wang, Xiaojie, Kolar, Matthew J, Puca, Francesca, Saghatelian, Alan, Plikus, Maksim V, Verma, Inder M, Panda, Satchidananda   +8 more
openaire   +4 more sources

Circadian Deregulation in Multiple Myeloma: BMAL1/CLOCK Expression Patterns and Diagnostic Performance

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Circadian clock disruption has emerged as a relevant axis in cancer; however, the expression patterns and diagnostic relevance of BMAL1 and CLOCK in multiple myeloma (MM) remain insufficiently defined. Methods BMAL1 and CLOCK mRNA expression was quantified by RT‐qPCR in bone marrow samples from 46 newly diagnosed MM patients and 13 ...
Hamide Albayrak, Mustafa Ertan Ay, Anıl Tombak, Kenan Çevik, Özlem İzci Ay, Tuba Kabasakal, Mehmet Emin Erdal   +6 more
wiley   +1 more source

Daily rhythms in expression of genes of hepatic lipid metabolism in Atlantic salmon (Salmo salar L.).

PLoS ONE, 2014
In mammals, several genes involved in liver lipid and cholesterol homeostasis are rhythmically expressed with expression shown to be regulated by clock genes via Rev-erb 1α.
Mónica B Betancor, Elsbeth McStay, Matteo Minghetti, Hervé Migaud, Douglas R Tocher, Andrew Davie   +5 more
doaj   +1 more source

Climate Shapes Elevational Gradients in Concentration, Composition, and Functional Diversity of Willow Metabolomes

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants produce broad spectra of metabolites comprising primary metabolites involved in core physiological processes and specialized metabolites mediating responses to biotic and abiotic stress. Understanding how these various components of the metabolome respond to different environmental pressures can help us to understand drivers of ...
Sofian A. Renoult, Priscila Mezzomo, Jing V. Leong, Pavel Sebek, Shristee Panthee, Jaroslav Kukla, Petr Nguyen, Martin Moos, Dale L. Forrister, Natascha D. Wagner, Elvira Hörandl, Petr Koutecký, Brian E. Sedio, Jan Frouz, Nicole M. van Dam, Martin Volf   +15 more
wiley   +1 more source

Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine

Frontiers in Immunology, 2020
The innate immune system senses “non-self” molecules derived from pathogens (PAMPs) as well as endogenous damage-associated molecular patterns (DAMPs) and promotes sterile inflammation that is necessary for injury resolution, tissue repair/regeneration ...
Benoit Pourcet, Hélène Duez
doaj   +1 more source

Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina. [PDF]

PLoS ONE, 2011
The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated by genes such as nuclear hormone receptors.
Nissa J Mollema, Yang Yuan, Austin S Jelcick, Andrew J Sachs, Désirée von Alpen, Daniel Schorderet, Pascal Escher, Neena B Haider   +7 more
doaj   +1 more source

The Astrocyte Clock Controls Circadian Perineuronal Net Remodeling, Synapse Strength and Learning Behavior

Glia, Volume 74, Issue 10, October 2026.
Bmal1 regulates astrocyte extracellular matrix (ECM) gene expression. Bmal1 deletion in astrocytes disrupts normal circadian rhythms in perineuronal nets (PNN) and reduces PNN content in the hippocampus. In parallel with loss of PNNs, deletion of the core circadian clock gene Bmal1 in astrocytes alters behavior and synaptic function in vivo.
Philip C. Smith, Elsa I. Quillin, Katheryn B. Lefton, Celia A. McKee, Brendan Dang, Thomas Papouin, Erik S. Musiek   +6 more
wiley   +1 more source