Results 71 to 80 of about 5,296 (150)

Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms.

PLoS Genetics, 2008
The mammalian circadian clockwork is composed of a core PER/CRY feedback loop and additional interlocking loops. In particular, the ROR/REV/Bmal1 loop, consisting of ROR activators and REV-ERB repressors that regulate Bmal1 expression, is thought to ...
Andrew C Liu, Hien G Tran, Eric E Zhang, Aaron A Priest, David K Welsh, Steve A Kay   +5 more
doaj   +1 more source

Biological Clock Rhythm Regulates Viral Resistance of Human Bodies [PDF]

E3S Web of Conferences
Virus has caused great distress to human health. Based on the lack of specific target sites and therapy of various viruses, this article highlights circadian rhythm, the biological clock that tells the body to do the correct thing according to the time ...
Li Xinbo
doaj   +1 more source

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha, Eloisa Vilas‐Boas, Camille C. Caldeira da Silva, Everton L. Vogt, Marcos Yoshinaga, Mariana Pacheco Teixeira de Carvalho, Maiara I. C. Queiroz, Tiago Eugênio Oliveira da Silva, Sayuri Miyamoto, Alicia J. Kowaltowski   +9 more
wiley   +1 more source

Hepatocyte SREBP signaling mediates clock communication within the liver

The Journal of Clinical Investigation, 2023
Rhythmic intraorgan communication coordinates environmental signals and the cell-intrinsic clock to maintain organ homeostasis. Hepatocyte-specific KO of core components of the molecular clock Rev-erbα and -β (Reverb-hDKO) alters cholesterol and lipid ...
Dongyin Guan, Hosung Bae, Dishu Zhou, Ying Chen, Chunjie Jiang, Cam Mong La, Yang Xiao, Kun Zhu, Wenxiang Hu, Trang Minh Trinh, Panpan Liu, Ying Xiong, Bishuang Cai, Cholsoon Jang, Mitchell A. Lazar   +14 more
doaj   +1 more source

Lectotypifications and taxonomic changes in the holoparasitic Orobanchaceae

Nordic Journal of Botany, Volume 2026, Issue 8, August 2026.
Based on further extensive studies of specimens in various herbaria, lectotypes are designated for many taxa of holoparasitic Orobanchaceae. In particular, 47 names in the genera Boschniakia (incl. Xylanche), Cistanche, Orobanche, Phelipanche and Phelypaea are lectotypified.
Holger Uhlich, Stefan Rätzel, Óscar Sánchez Pedraja, Renata Piwowarczyk, Valerio Lazzeri, Patrice Descombes   +5 more
wiley   +1 more source

Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual‐Purpose Defense Metabolite in Sorghum bicolor

Plant Direct, Volume 10, Issue 8, August 2026.
ABSTRACT Dhurrin, a cyanogenic glucoside, plays an important role in Sorghum bicolor physiology and defense. The concentration of dhurrin in sorghum is influenced by both nitrogen status and stage of plant organ development. While nitrogen resupply activates the expression of genes for dhurrin biosynthesis, the molecular mechanisms underlying this ...
Alicia A. Quinn, Brian A. McKinley, Cecilia K. Blomstedt, John E. Mullet, Roslyn M. Gleadow   +4 more
wiley   +1 more source

Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice

Cell Reports
Summary: Circadian rhythms control the diurnal nature of many physiological, metabolic, and immune processes. We hypothesized that age-related impairments in circadian rhythms are associated with high susceptibility to bacterial respiratory tract ...
Fabiola Silva Angulo, Claudine Vanessa Joseph, Lou Delval, Lucie Deruyter, Séverine Heumel, Marie Bicharel, Patricia Brito Rodrigues, Valentin Sencio, Tom Bourguignon, Marina Gomes Machado, Marie Fourcot, Stéphane Delhaye, Sophie Salomé-Desnoulez, Philippe Valet, Serge Adnot, Isabelle Wolowczuk, Jean-Claude Sirard, Muriel Pichavant, Bart Staels, Joel T. Haas, Ruxandra Gref, Jimmy Vandel, Arnaud Machelart, Hélène Duez, Benoit Pourcet, François Trottein   +25 more
doaj   +1 more source

Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment efficacy and toxicity depend not only on the choice of therapy but also on its timing relative to the patient's internal ...
Andrej Belančić, Marko Skelin, Yun Wah Lam, Almir Fajkić, Bruna Perkov‐Stipičin, Rossana Roncato, Ivan Krečak, Marko Lucijanić   +7 more
wiley   +1 more source

Adropin: An endocrine link between the biological clock and cholesterol homeostasis

Molecular Metabolism, 2018
Objective: Identify determinants of plasma adropin concentrations, a secreted peptide translated from the Energy Homeostasis Associated (ENHO) gene linked to metabolic control and vascular function.
Sarbani Ghoshal, Joseph R. Stevens, Cyrielle Billon, Clemence Girardet, Sadichha Sitaula, Arthur S. Leon, D.C. Rao, James S. Skinner, Tuomo Rankinen, Claude Bouchard, Marinelle V. Nuñez, Kimber L. Stanhope, Deborah A. Howatt, Alan Daugherty, Jinsong Zhang, Matthew Schuelke, Edward P. Weiss, Alisha R. Coffey, Brian J. Bennett, Praveen Sethupathy, Thomas P. Burris, Peter J. Havel, Andrew A. Butler   +22 more
doaj   +1 more source

Direct and indirect effects of elevated CO2, warming and drought on plant–consumer interactions of Plantago lanceolata

Journal of Ecology, Volume 114, Issue 8, August 2026.
Experimental treatments of warming, elevated CO2, drought and their interactions had direct and indirect (plant‐trait‐mediated) effects on field Plantago lanceolata consumption and feeding preferences of the locust Locusta migratoria. The effects largely differed between consumption types, despite being studied on the same species in the same system ...
Micha Davidová, Dinesh Thakur, Michael Bahn, Andreas Schaumberger, Nikita Rathore, Jaroslav Semerád, Tomáš Cajthaml, Zuzana Münzbergová   +7 more
wiley   +1 more source