Results 91 to 100 of about 5,296 (150)

Regulating the Clock: REV-ERB Agonists as Promising Therapeutic Agents. [PDF]

GEN Biotechnol, 2023
Prasad C, Sundar IK.
europepmc   +1 more source

A Theoretical Study of Glucagon-Mediated Feedback in the Mammalian Circadian Clock

Mathematics
The circadian clock is closely linked to glucose regulation, but the dynamical consequences of specific metabolic feedback pathways on core clock regulation remain incompletely understood.
Tingwei Liang, Feng Yu, Jie Yan
doaj   +1 more source

Light Exposure, Physical Activity, and Indigeneity Modulate Seasonal Variation in NR1D1 (REV-ERBα) Expression

Biology
Nuclear receptor subfamily 1 group D member 1 (NR1D1 or REV-ERBα) is a crucial element of the circadian clock’s transcriptional and translational feedback loop.
Denis Gubin, Sergey Kolomeichuk, Konstantin Danilenko, Oliver Stefani, Alexander Markov, Ivan Petrov, Kirill Voronin, Marina Mezhakova, Mikhail Borisenkov, Aislu Shigabaeva, Julia Boldyreva, Julianna Petrova, Dietmar Weinert, Germaine Cornelissen   +13 more
doaj   +1 more source

CHRONO regulates the circadian clock via the REV-ERBα – BMAL1 loop

npj Biological Timing and Sleep
The period length of the circadian clock is important for organisms to maintain homeostasis. CHRONO has been shown to play an important role in regulating the period of the mammalian clock and has recently been implicated to function in several important
Qin Zhou, Lanxin Gao, Ruohan Wang, Shaoying Lan, Dan Li, Ximing Qin   +5 more
doaj   +1 more source

Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox. [PDF]

Circulation, 2022
Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q, Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J, Zhang L, Sun Z.   +25 more
europepmc   +1 more source

Chronic low-dose REV-ERBs agonist SR9009 mitigates constant light-induced weight gain and insulin resistance via adipogenesis modulation

Biomedical Journal
Background: Obesity and circadian rhythm disruption are significant global health concerns, contributing to an increased risk of metabolic disorders. Both adipose tissue and circadian rhythms play critical roles in maintaining energy homeostasis, and ...
Ming-Yu Yang, Hugo Y.-H. Lin, Yi-Ywan M. Chen, Ming-Luen Hu, I-Ya Chen, Chao-Hui Yang   +5 more
doaj   +1 more source

Sinapic Acid Ameliorates REV-ERB α Modulated Mitochondrial Fission against MPTP-Induced Parkinson's Disease Model. [PDF]

Biomol Ther (Seoul), 2022
Lee SB, Yang HO.
europepmc   +1 more source

REV-ERB nuclear receptors in the suprachiasmatic nucleus control circadian period and restrict diet-induced obesity. [PDF]

Sci Adv, 2021
Adlanmerini M, Krusen BM, Nguyen HCB, Teng CW, Woodie LN, Tackenberg MC, Geisler CE, Gaisinsky J, Peed LC, Carpenter BJ, Hayes MR, Lazar MA.   +11 more
europepmc   +1 more source

Posttranslational Modifications of Rev-Erbα Protein and Abnormal Inflammatory Response in Gastric Cancer. [PDF]

J Oncol, 2022
Ke C, Xiaowen C, Yufeng W, Dongchang L, Huaqing Z, Zhengguang W.   +5 more
europepmc   +1 more source

SR8278 inhibits cell proliferation independent of REV-ERB

Abstract Background The small molecule SR8278 was initially identified as an antagonist of the REV-ERB (reverse c-ERBAa) nuclear receptor proteins, which play an important role in metabolism and circadian rhythms. Though SR8278 has been shown to have beneficial physiological effects in a variety of preclinical disease contexts, its ...
Ushaswini Atluri, William Cvammen, Michael G. Kemp   +2 more
openaire   +1 more source