Results 111 to 120 of about 5,296 (150)

Exhaustive exercise abolishes REV-ERB-α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice. [PDF]

J Physiol
da Rocha AL, Pinto AP, de Sousa Neto IV, Muñoz VR, Marafon BB, da Silva LECM, Pauli JR, Cintra DE, Ropelle ER, Simabuco FM, de Moura LP, de Freitas EC, Rivas DA, da Silva ASR.   +13 more
europepmc   +1 more source

The Circadian Clock Component REV-ERB Is an Analgesic Target for Cancer-Induced Tactile Pain Hypersensitivity. [PDF]

J Neurosci
Yasukochi S, Yamakawa W, Taniguchi M, Itoyama S, Tsuruta A, Kusunose N, Yamauchi T, Nakamura R, Matsunaga N, Ohdo S, Koyanagi S.   +10 more
europepmc   +1 more source

Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia. [PDF]

Proc Natl Acad Sci U S A
Kelu JJ, Hughes SM.
europepmc   +1 more source

Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy. [PDF]

J Med Chem
Palomba M, Vecchio D, Allavena G, Capaccio V, De Mei C, Scarpelli R, Grimaldi B.   +6 more
europepmc   +1 more source

SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy. [PDF]

Theranostics, 2020
Shen W, Zhang W, Ye W, Wang H, Zhang Q, Shen J, Hong Q, Li X, Wen G, Wei T, Zhang J.   +10 more
europepmc   +1 more source

The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock. [PDF]

Int J Mol Sci, 2019
Ishimaru K, Nakajima S, Yu G, Nakamura Y, Nakao A.   +4 more
europepmc   +1 more source

Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass. [PDF]

Sci Rep, 2017
Mayeuf-Louchart A, Thorel Q, Delhaye S, Beauchamp J, Duhem C, Danckaert A, Lancel S, Pourcet B, Woldt E, Boulinguiez A, Ferri L, Zecchin M, Staels B, Sebti Y, Duez H.   +14 more
europepmc   +1 more source

Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle. [PDF]

Sci Rep, 2017
Welch RD, Billon C, Valfort AC, Burris TP, Flaveny CA.   +4 more
europepmc   +1 more source

The transcriptional repressor REV-ERB as a novel target for disease

Bioorganic and Medicinal Chemistry Letters, 2020
REV-ERB is a member of the nuclear receptor superfamily of transcription factors involved in the regulation of many physiological processes, from circadian rhythm, to immune function and metabolism. Accordingly, REV-ERB has been considered as a promising, but difficult drug target for the treatment of numerous diseases.
, Matthew Fuchter, Hugh Brady
exaly   +4 more sources