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REV-ERBs negatively regulate mineralization of the cementoblasts
Biochemical and Biophysical Research Communications, 2022The role of circadian clock in cementogenesis is unclear. This study examines the role of REV-ERBs, one of circadian clock proteins, in proliferation, migration and mineralization of cementoblasts to fill the gap in knowledge.Expression pattern of REV-ERBα in cementoblasts was investigated in vivo and in vitro. CCK-8 assay, scratch wound healing assay,
Liangliang Fu +6 more
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REV-ERB and ROR: therapeutic targets for treating myopathies
Physical Biology, 2017Muscle is primarily known for its mechanical roles in locomotion, maintenance of posture, and regulation of cardiac and respiratory function. There are numerous medical conditions that adversely affect muscle, myopathies that disrupt muscle development, regeneration and protein turnover to detrimental effect.
Ryan D Welch, Colin A Flaveny
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REV-ERB Agonists Block Autophagy in Cancer Cells
Cancer Discovery, 2018Abstract Disruption of the circadian clock components reduces cancer cell viability in vitro and in vivo.
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Rev-erb beta 2, a novel isoform of the Rev-erb family of orphan nuclear receptors.
Biochemistry and molecular biology international, 1996We have isolated a rat complementary DNA clone corresponding to a novel isoform of the hormone nuclear receptor superfamily. This clone encodes a 383 amino acid residue protein designated as Rev-erb beta 2. This protein is identical until residue 382 to the Rev-erb beta 1 protein, which is 195 amino acids longer.
N, Giambiagi +6 more
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Rev-erb alpha gives a time cue to metabolism.
FEBS letters, 2008Normal physiological processes are under control of circadian rhythms. Moreover, certain pathological events, such as cardiovascular accidents (myocardial infarction, stroke) occur more frequently at specific times of the day. Recent observations demonstrate a causal relationship between alterations in circadian rhythmicity and metabolic disorders ...
Hélène, Duez, Bart, Staels
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Optimized chemical probes for REV-ERB alpha
2013REV-ERB alpha has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERB alpha agonists based on G5K4112 (1) for potency, selectivity, and bioavailability.(1) Potent REV-ERB alpha agonists 4, 10, 16, and 23 are detailed for their ability to suppress ...
Trump, Ryan P. +15 more
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Rev-erb–Mediated Regulation of Cardiac Metabolism in the Obesity Paradox
Circulation, 2022Inna Rabinovich-Nikitin +1 more
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