Results 151 to 160 of about 39,620 (261)

The median preoptic nucleus is a key site for estradiol regulation of sleep-wake behaviors in females rats. [PDF]

open access: yesSleep
Kruk K   +7 more
europepmc   +1 more source

Accelerated Biological Aging, Neurodegenerative Disease, and Mortality in Cardiovascular Disease Patients: Mediation and Modification Analysis

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
In cardiovascular disease (CVD) patients, accelerated biological aging is independently associated with elevated mortality risk, which is mediated by neurodegenerative disease. Early‐onset CVD amplifies the mortality risk, whereas a healthy lifestyle confers partial protection.
Jinyue Li, Han Ma, Guohua Wang
wiley   +1 more source

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

open access: yesComprehensive Physiology, Volume 16, Issue 4, August 2026.
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha   +9 more
wiley   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

open access: yesInternational Journal of Cancer, Volume 159, Issue 3, Page 768-781, 1 August 2026.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente   +12 more
wiley   +1 more source

A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Environmental toxicants may disrupt developmental pathways via strong molecular docking interactions with hub FGF proteins (FGF9 and FGF4) like dibenzo‐p‐dioxin (−7.2 kcal/mol) at the ASN146 residue of FGF9, driving congenital malformations as revealed by PPI networks and toxicity profiling.
Adarsh Kumar Shukla   +3 more
wiley   +1 more source

Psychometric Evaluation and Clinical Norms of a Dutch Version of the Body Uneasiness Test Among Individuals With Self‐Reported Eating Disorder Pathology

open access: yesJournal of Clinical Psychology, Volume 82, Issue 8, Page 1177-1187, August 2026.
ABSTRACT Introduction The present study evaluates the psychometric properties and provides normative data for the Dutch Body Uneasiness Test. The instrument was administered to a clinical sample (N = 448) and a community‐based sample (N = 223). The Body Uneasiness Test was translated and back‐translated.
Lanaya M. van Uffelen   +2 more
wiley   +1 more source

Editorial Expression of Concern: Two novel human anti-ErbB2 immunoagents are active on trastuzumab-resistant tumours. [PDF]

open access: yesBr J Cancer
Gelardi T   +8 more
europepmc   +1 more source

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