Role of ErbB receptors in cancer cell migration and invasion [PDF]
Frontiers in Pharmacology, 2015 Growth factors mediate their diverse biologic responses (regulation of cellular proliferation, differentiation, migration and survival) by binding to and activating cell-surface receptors with intrinsic protein kinase activity named Receptor Tyrosine ...
Aline eAppert-Collin +4 more
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Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer [PDF]
Biomedicines, 2023 Overexpression and mutations of the epidermal growth factor receptor (EGFR/ErbB1/HER1) and other tyrosine kinase receptors of the ErbB family (ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4) play an essential role in enhancing the proliferation, the migratory ...
Antonio Villalobo
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The Role of ErbB Receptors in Infection. [PDF]
Trends Microbiol, 2017 Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis.
Ho J, Moyes DL, Tavassoli M, Naglik JR.
europepmc +7 more sources
Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma [PDF]
Frontiers in Medicine, 2023 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type, has often an aggressive course and is poorly responsive to current therapeutic approaches, so that 5-year survival rates for patients diagnosed with advanced disease is ...
Camilla Palumbo +13 more
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Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo [PDF]
Journal of Translational Medicine, 2022 Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM.
Roberto Bei +17 more
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L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]
PLoS ONE, 2012 During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Emanuelle Donier +6 more
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Translocation of ErbB receptors into the nucleus [PDF]
Revista de Oncología, 2013 The ErbB receptors are tyrosine kinases that bind a wide variety of ligands. They are implicated in cell proliferation, generation of anti-apoptotic signals, differentiation, and cell migration.
Molina-Martínez, Patricia +2 more
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Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists [PDF]
iScienceSummary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović +10 more
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ErbB receptors and signaling pathways in cancer.
Current Opinion in Cell Biology, 2009 The ErbB receptor tyrosine kinases play important roles in normal physiology and in cancer. Epidermal growth factor receptor (EGFR) and ErbB2 in particular are mutated in many epithelial tumors, and clinical studies suggest that they play roles in cancer
Mac Donald, Gwen, Hynes, Nancy
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The ErbB receptors and their role in cancer progression.
Experimental Cell Research, 2003 The involvement of the ErbB receptor tyrosine kinases in human cancer, as well as their essential role in a variety of physiological events during normal development, have motivated the interest in this receptor family.
Holbro T, Hynes NE, Civenni G
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