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The ErbB Receptors as Targets for Breast Cancer Therapy
Journal of Mammary Gland Biology and Neoplasia, 1999Breast carcinomas express high levels of ErbB receptors and their ligands, and their overexpression has been associated with a more aggressive clinical behavior. For these reasons therapies directed at these receptors have the potential to be useful anti-cancer treatments.
J, Albanell, J, Baselga
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Expression of erbB receptors mRNA in thyroid tissues
Biochimica et Biophysica Acta (BBA) - General Subjects, 2004ErbB family members, such as epidermal growth factor receptor 1 (erbB1), erbB2, erbB3 and erbB4, are widely distributed in organ tissues, and these receptors are suspected tumorigenesis factors. We measured erbB mRNA in thyroid tissues of benign and malignant thyroid tumors or Graves' disease using Genescan.
Seiya, Kato +8 more
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The erbB gene and the EGF receptor.
Cancer surveys, 1987The epidermal growth factor (EGF) receptor is a plasma membrane glycoprotein. It contains four distinct segments: an N-terminal EGF binding domain which is exposed at the cell surface; a short transmembrane segment; a cytoplasmic domain with protein-tyrosine kinase activity; and a C-terminal regulatory segment.
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