Results 41 to 50 of about 610,538 (183)
Identification of nucleolin as new ErbB receptors- interacting protein.
PLoS ONE, 2008 BackgroundThe ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas.
Ayelet Di Segni +2 more
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Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis
BMC Evolutionary Biology, 2006 Background In the time since we presented the first molecular evolutionary study of the ErbB family of receptors and the EGF family of ligands, there has been a dramatic increase in genomic sequences available. We have utilized this greatly expanded data
Staros James V, Stein Richard A
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Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. [PDF]
PLoS ONE, 2010 The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is
Victoria E Abraira +3 more
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EGFR Signaling in Lung Fibrosis
Cells, 2022 In this review article, we will first provide a brief overview of the ErbB receptor–ligand system and its importance in developmental and physiological processes.
Fabian Schramm +2 more
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Targeting the Calmodulin-Regulated ErbB/Grb7 Signaling Axis in Cancer Therapy
Journal of Pharmacy & Pharmaceutical Sciences, 2013 Signal transduction pathways essential for the survival and viability of the cell and that frequently present aberrant expression or function in tumors are attractive targets for pharmacological intervention in human cancers. In this short review we will
Antonio Villalobo +3 more
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PLoS ONE, 2008 BackgroundTamoxifen is still the most widely used drug in hormone therapy for the treatment of breast cancer. Its benefits in adjuvant treatment are well documented in controlled and randomized clinical studies, which have demonstrated an increase in ...
Valentina Folgiero +14 more
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An investigation of the role of the ErbB receptor family in chemotherapeutic drug resistance and invasion in human breast cancer [PDF]
, 2002 The purpose of the work described in this thesis was to investigate the effects of upregulation of c-erbB-2 by cDNA transfection and the downregulation by ribozyme transfection on chemotherapeutic drug sensitivity, in vitro invasion, and expression of a ...
Glynn, Sharon
core +2 more sources
Scientific Reports, 2017 Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri +2 more
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Molecular Mechanisms, Expression and Clinical Role of ErbB Receptors in Endometrial Cancer [PDF]
, 2015 The epidermal growth factor system (EGF System) is present in various human organs. It has 4 receptors (EGFR, ErbB-2, ErbB-3 and ErbB-4) and numerous ligands.
Adonakis G +3 more
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Phosphotyrosine interactome of the ErbB‐receptor kinase family [PDF]
Molecular Systems Biology, 2005 Interactions between short modified peptide motifs and modular protein domains are central events in cell signal-transduction. We determined interaction partners to all cytosolic tyrosine residues of the four members of the ErbB-receptor family in an unbiased fashion by quantitative proteomics using pull-down experiments with pairs of phosphorylated ...
Schulze, W. X., Deng, L., Mann, Matthias
openaire +4 more sources