Results 121 to 130 of about 575,775 (211)

Binding specificities and affinities of egf domains for ErbB receptors [PDF]

, 1999
ErbB receptor activation is a complex process and is dependent upon the type and number of receptors expressed on a given cell. Previous studies with defined combinations of ErbB receptors expressed in mammalian cells have helped elucidate specific ...
Sliwkowski, Mark X, Robert W Akita, Jennifer T Jones, Akita, Robert W, Mark X Sliwkowski, Jones, Jennifer T   +5 more
core   +1 more source

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

Aging Cell, Volume 25, Issue 9, September 2026.
Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation in LMNA that produces the toxic progerin protein. In this study, an adenine base editor delivered via AAV9 achieved partial gene correction in HGPS mice when given at two weeks of age, partially rescuing bone structural and gene expression parameters and ...
Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan, Indeevar Beeram, Shubham Laiwala, Lukas R. Johnson, Urraca L. Tavarez, Tingfen Yan, Stephen M. Wincovitch, Luke W. Koblan, Xin D. Gao, Meirui An, Narisu Narisu, Leslie G. Biesecker, David R. Liu, Ara Nazarian, Francis S. Collins, Michael R. Erdos   +17 more
wiley   +1 more source

The role of estrogen receptors, erbB receptors, vascular endothelial growth factor and its receptors, and vascular endothelial growth inhibitor in the development of the rat mammary gland

, 2010
We identified the localization and distribution of cell-specific epidermal growth factor receptors (EGFRs erbB-1, erbB-2, erbB-3, erbB-4), vascular endothelial growth factor (VEGF), VEGF receptors [VEGFRs VEGF-R1 (fit-1), VEGF-R2 (flk-1/KDR), VEGF-R3 ...
Hakan Sagsoz, Muzaffer Aydin Ketani, Ketani, Muzaffer Aydin, Sagsoz, Hakan   +3 more
core   +1 more source

Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]

, 2014
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Goltsov, Alexey, Stylianos Kyriakidis, Hilal Khalil, Simon P. Langdon, Harrison, David James, Langdon, Simon P., Bown, James L., Khalil, Hilal S., Simon Langdon, Tero Soininen, Khalil, Hilal S, Soininen, Tero, Alexey Goltsov, Huizhong Hu, David J. Harrison, Bown, James, David Harrison, Deeni, Yusuf, Harrison, David J, Kyriakidis, Stylianos, Hu, Huizhong, Deeni, Yusuf Y.; id_orcid, Yusuf Deeni, Hilal S. Khalil, Langdon, Simon P, James Bown, Harrison, David J.   +26 more
core   +1 more source

Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells. [PDF]

Cancers (Basel), 2022
Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A.   +9 more
europepmc   +1 more source

Signaling through ERBB receptors: Multiple layers of diversity and control

, 2006
The four known ERBB receptors in humans are involved in a broad range of cellular responses, and their deregulation is a significant aspect in a large number of disease states.
Warren, Carmen M, Landgraf, Ralf
core   +1 more source

The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease

Biomarker Insights, 2015
Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function.
Cassady E. Rupert, Kareen L.K. Coulombe
doaj   +1 more source

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

Molecular Systems Biology, 2009
The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis.
William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger, Peter K Sorger   +6 more
doaj   +1 more source

ErbB signaling in brain injury regeneration: Pathway interactions and therapeutic potential

Neural Regeneration Research
The ErbB signaling network has recently emerged as a key modulator of central nervous system responses to injury. This review provides a comprehensive overview of ErbB receptors and their ligands, highlighting canonical and non-canonical signaling ...
Patricia Pérez-García, Nora Martínez-Gómez, Sonia Vázquez-de Górgolas, Andrea Chamorro-Francisco, Ricardo Pardillo-Díaz, Pedro Nunez-Abades, Carmen Castro, Livia Carrascal   +7 more
doaj   +1 more source

Additional file 1: of Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

, 2017
Buformin does not upregulate AMPK activation in MMTV-erbB-2 mice. Representative images of p-AMPK immunostained mammary tissues from 18-week-old MMTV-erbB-2 mice that were fed control or buformin diets for 10 weeks are shown.
Amanda Parris (3744949), Ming Zhao (48501), Erin Howard (3744951), Zhikun Ma (309630), Xiaohe Yang (3744947), Qingxia Zhao (789655)   +5 more
core   +1 more source