Results 141 to 150 of about 610,538 (183)

Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination. [PDF]

Nat Commun
Ziaee SM, Nemati S, Kataria H, Jakova E, Hosseini SM, Ghelich P, McLeod G, Tamayol A, Yong VW, Karimi-Abdolrezaee S.   +9 more
europepmc   +1 more source

Systemic Drug Effects in Vortioxetine-Induced Time-Series Datasets. [PDF]

Int J Mol Sci
Kim S.
europepmc   +1 more source

Cancer Genes: Origins and Directions. [PDF]

Viruses
Vogt PK.
europepmc   +1 more source

Genomic Landscape Analysis of Canine Pulmonary Adenocarcinoma Reveals Candidate Targetable Gene Fusions. [PDF]

Vet Comp Oncol
Sakthikumar S, Hendricks WPD, Rainford D, Selleck W, Briones N, Coggins C, Quan N, Zismann V, Lorch G, Sekulic A, Trent JM.   +10 more
europepmc   +1 more source

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The EGF/ErbB Receptor Family and Apoptosis

Growth Factors, 2002
The ErbB receptor family can activate a multitude of cell signaling pathways that involve many aspects of cellular function. The four members of the ErbB receptor family interact with diverse ligands and substrates, as well as with each other through cell surface heterodimerization.
Nita J Maihle
exaly   +3 more sources

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4 [PDF]

Oncogene, 1997
Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain characteristics that are different from that of EGF, including mitogenic responses and binding to EGF receptor (EGFR). Epiregulin may also have another cell surface receptor and/or induces different receptor heterodimerizations for intracellular signaling.
T Komurasaki, Toshi Komurasaki, Shigeo Morimoto   +2 more
exaly   +3 more sources

Interaction of antibodies with ErbB receptor extracellular regions [PDF]

Experimental Cell Research, 2009
Antibodies to the extracellular region of the ErbB receptors have played key roles in the development of a mechanistic understanding of this family of receptor tyrosine kinases. An extensively studied class of such antibodies inhibits activation of ErbB receptors, and these antibodies have been the focus of intense development as anti-cancer agents. In
Kathryn M. Ferguson, Karl R Schmitz
exaly   +3 more sources

ErbB receptors and their ligands in the breast

Expert Reviews in Molecular Medicine, 2006
ErbB receptor tyrosine kinases are membrane-bound receptors that possess intrinsic, ligand-activated, tyrosine kinase activity. Binding of growth factors to these receptors induces the formation of ErbB homo- and heterodimers and initiates a signalling cascade that traverses the cytoplasm to communicate with the nucleus and the cytoskeleton. The effect
openaire   +2 more sources

The ErbB Receptors and their Ligands in Cancer: An Overview

Current Drug Targets, 2005
This review article provides an overview on the most recent advances on the role of ErbB receptors and growth factors of the epidermal growth factor (EGF)-family of peptides in cancer pathogenesis and progression. The ErbB tyrosine kinases and the EGF-like peptides form a complex system. In fact, the interactions occurring between receptors and ligands
N, Normanno, C, Bianco, L, Strizzi, M, Mancino, M R, Maiello, A, De Luca, F, Caponigro, D S, Salomon   +7 more
openaire   +2 more sources