Results 171 to 180 of about 253 (229)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, Volume 20, Issue 8, Page 2023-2039, August 2026.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, Volume 13, Issue 44, 7 August 2026.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, Volume 13, Issue 46, 17 August 2026.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, Volume 13, Issue 44, 7 August 2026.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown. METHODS We utilized in silico analyses of published databases, MIR155‐deleted and ‐overexpressing human induced pluripotent stem cell ...
Xiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al‐subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich   +10 more
wiley   +1 more source

Aharonov–Bohm Effect for Cooper Pairs in Kerr Spacetime: Gravitomagnetic Phase Shifts From Frame Dragging

Annalen der Physik, Volume 538, Issue 8, August 2026.
ABSTRACT The unification of quantum mechanics and general relativity remains a central problem in fundamental physics. Here, we study the gravitomagnetic Aharonov–Bohm (AB) effect for Cooper pairs in Kerr spacetime. Frame‐dragging by a rotating black hole (BH) generates an effective vector potential through the off‐diagonal metric term gtϕ$g_{t\phi }$,
Erdem Sucu, İzzet Sakallı
wiley   +1 more source

Acute and Chronic Effects of Aerobic Exercise on Motor Inhibition and Cortical Excitability in Adolescents With Attention Deficit Hyperactivity Disorder

Brain and Behavior, Volume 16, Issue 8, August 2026.
In adolescents with ADHD, acute and chronic aerobic exercise enhance motor inhibition. Chronic exercise yields greater benefits and reduces cortical excitability, linking behavioral gains to neurophysiological changes. These findings support sustained exercise as a therapeutic strategy for improving inhibitory control.
Jia‐Ling Sun, Jung‐Chi Chang, Pou‐Leng Cheong, Hsiao‐I Kuo   +3 more
wiley   +1 more source

Primary Cervical Angiosarcoma Presenting With Transfusion‐Dependent Bleeding in Early Pregnancy: Diagnostic and Management Challenges

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Persistent vaginal bleeding during pregnancy should not be attributed solely to obstetric causes. Rare cervical malignancies, including angiosarcoma, may present with life‐threatening anemia, and MRI with early biopsy is essential to avoid diagnostic delay.
Ammir Abuzahra, Ruba Atawneh, Siwar Abu Sakout, Raya Abu Ayyash, Jana Dwaik   +4 more
wiley   +1 more source

Chondroid Soft Tissue Tumors With FOS::PABPN1 Fusion: A New Entity? About Two Cases

Genes, Chromosomes and Cancer, Volume 65, Issue 8, August 2026.
ABSTRACT Soft tissue tumors with chondroid matrix represent a heterogeneous group with persistent diagnostic challenges. Advances in molecular diagnostics have identified recurrent gene fusions in several chondroid neoplasms, predominantly involving FN1. Here, we report two cases of chondroid tumors harboring a novel FOS::PABPN1 fusion.
Jinane Kharmoum, Alexendra Meurgey, Daniel pissaloux, Sanae Chaib, Nicolas Macagno, Mariame Chraibi, Franck Tirode, Marie Karanian   +7 more
wiley   +1 more source

Ergativity and so-called 'ergative of'

Ergativity and so-called 'ergative of'
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