Results 81 to 90 of about 22,371 (191)

Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Mitochondria respond to proteotoxic stress through the mitochondrial unfolded protein response, traditionally viewed as a transcriptional program that restores proteostasis by inducing chaperones and proteases. Emerging evidence indicates that mitochondrial membrane remodeling constitutes an additional adaptive component of this response ...
Lena J. Reichert, F.‐Nora Vögtle, Carlotta Peselj   +2 more
wiley   +1 more source

Ergosterol Biosynthesis and Regulation Impact the Antifungal Resistance and Virulence of Candida spp.

Stresses
Ergosterol is a key fungal sterol that is mainly found in the plasma membrane and is responsible for the proper membrane structure, rigidity, permeability and activity of membrane proteins. Ergosterol plays a crucial role in the ability of fungi to adapt
Daniel Eliaš, Nora Tóth Hervay, Yvetta Gbelská   +2 more
doaj   +1 more source

Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth[S]

Journal of Lipid Research, 2015
Ergosterol biosynthesis and homeostasis in the parasitic protozoan Trypanosoma brucei was analyzed by RNAi silencing and inhibition of sterol C24β-methyltransferase (TbSMT) and sterol 14α-demethylase [TbSDM (TbCYP51)] to explore the functions of sterols ...
Brad A. Haubrich, Ujjal K. Singha, Matthew B. Miller, Craigen R. Nes, Hosanna Anyatonwu, Laurence Lecordier, Presheet Patkar, David J. Leaver, Fernando Villalta, Benoit Vanhollebeke, Minu Chaudhuri, W. David Nes   +11 more
doaj   +1 more source

Emerging Antifungal Resistance in Tropical Mycoses: A Genomic and Clinical Perspective From Endemic Zones

Journal of the Royal Society of New Zealand, Volume 56, Issue 4, August 2026.
Antifungal resistance in tropical mycoses is an increasingly important component of the global antimicrobial resistance crisis, particularly in endemic regions where diagnostic capacity, therapeutic options, and surveillance systems are limited. This review synthesizes clinical, environmental, and genomic evidence on resistance in major endemic and ...
Meral Miraloglu
wiley   +1 more source

Ectomycorrhizal community composition and extramatrical hyphal proportion predict soil carbon stocks at the landscape scale

Functional Ecology, Volume 40, Issue 8, Page 2490-2505, August 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract While fungal composition has been linked to soil carbon at global scales, these patterns are often difficult to disentangle from broad climatic gradients and species range limits. To address this constraint, we tested which aspects of ectomycorrhizal community structure
Robert A. Barber, Benjamin C. Underwood, James J. Clarkson, Thomas D. Brekke, Thomas L. Weeks, Tim Wilkinson, Phil Wilkes, Gary Egan, Mark A. Lee, Isabel Openshaw, Guilherme Castro, Justin Moat, Martin I. Bidartondo, Laura M. Suz, Jill Kowal   +14 more
wiley   +1 more source

Synthesis of Ergosterol Peroxide Conjugates as Mitochondria Targeting Probes for Enhanced Anticancer Activity

Molecules, 2019
Inspired by the significant bioactivity of ergosterol peroxide, we designed and synthesized four fluorescent coumarin and ergosterol peroxide conjugates 8a−d through the combination of ergosterol peroxide with 7-N,N-diethylamino coumarins ...
Ming Bu, Hongling Li, Haijun Wang, Jing Wang, Yu Lin, Yukun Ma   +5 more
doaj   +1 more source

Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto, Kelly Lopes Figueira, Raquel Azevedo, Ketlym da Conceição, Ludmila de Ferreira de Almeida Fiuza, Luan dos Santos Vianna, Thiago Apolinário de Moraes, Wagner Alves de Souza Júdice, Maria de Nazaré Correia Soeiro, Jones Limberger   +9 more
wiley   +1 more source

Feeding black soldier fly (Hermetia illucens) larvae with mushrooms and then exposing them to UVB produces larvae extremely rich in vitamins D2 and D3

Future Foods
Black soldier fly larvae (BSFL) are a sustainable source of protein for feed but they can also be a sustainable source of some phytochemicals due to their ability to bioaccumulate them.
Lisa Morand-Laffargue, Florence Charles, Charlotte Sabran, Patrick Borel   +3 more
doaj   +1 more source

Composition of Oil and its Antifungal Activity by Disrupting Ergosterol Biosynthesis

Natural Product Communications, 2013
Cassia fistula oil was investigated for antifungal activities against standard and clinical isolates of Candida species. Gas chromatography coupled with mass spectrometric (GC-MS) analysis of C.
Md. Irshad, Aijaz Ahmad, Md. Zafaryab, Farah Ahmad, Nikhat Manzoor, Man Singh, M. Moshahid A. Rizvi   +6 more
doaj   +1 more source

Notes on the irradiation of ergosterol [PDF]

Biochemical Journal, 1928
T A, Webster, R B, Bourdillon
openaire   +2 more sources