Results 51 to 60 of about 8,478 (179)

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Ulcerações perianais por supositórios contendo ergotamina.

Acta Médica Portuguesa, 1992
Perianal ulcerations caused by suppositories application is an exceptional situation. We describe a 64 years old female with recurrent painless perianal ulcerations evoluting from 14 months.
A P Baptista, A Mariano, A Machado
doaj   +1 more source

Investigations with GMC2021 in experimental models predictive of antimigraine activity and coronary side-effect potential [PDF]

, 1996
Several acutely acting antimigraine drugs, including sumatriptan and other second generation 5-HT1D receptor agonists, have the ability to constrict porcine carotid arteriovenous anastomoses as well as the human isolated coronary artery.
Barf, R.P. (Paulien), Bax, W.A. (Willem), Heiligers, J.P. (Jan), Maassen van den Brink, A. (Antoinette), Saxena, P.R. (Pramod Ranjan), Vries, P.A.M. (Peter) de, Wikström, M. (Mats)   +6 more
core   +1 more source

Microneedles for the treatment of migraine and orofacial pain: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Migraine is a common neurological disorder and a primary headache condition. Despite its central origin, migraine pain may be referred to the orofacial region via trigeminal pathways, resulting in phenotypic overlap with other orofacial pain (OFP) conditions.
Baicheng Cao, Qiuyi Chen, Yuhan Liu, Ruozhou Wu, Bin Li, Qing Cai, Lu Liu   +6 more
wiley   +1 more source

Linking Photophobia, Sleep Disturbances, and Migraine Chronicity: Evidence From a Retrospective Analysis

Brain and Behavior, Volume 16, Issue 3, March 2026.
This study demonstrated that ictal photophobia was present in 89.8% and interictal photophobia in 93.4% of patients. Sleep disturbances were common, with 44.9% reporting difficulty falling asleep. Network analysis revealed stronger associations between interictal photophobia, daytime sleepiness, and medication overuse in chronic migraine compared to ...
Seden Demirci, Ezgi Uludüz, Sevim Eyüboğlu, Fatma Yardibi, Damla Hazal Sucu, Utku Topbaş, Aynur Özge, Derya Uludüz   +7 more
wiley   +1 more source

Ergotamina y terapia antiretroviral: una combinación peligrosa. Reporte de caso

Infectio, 2022
Ergotism is a rare clinical condition characterized by generalized vasoconstriction produced by the administration of Ergot-derived drugs. Primarily mediated by drug interactions, including antibiotics, oral contraceptives, and antivirals. We present the
Juan M. Hernandez-Torres
doaj   +1 more source

Comprehensive assessment of erenumab efficacy in participants with high‐frequency episodic migraine with at least one previously failed preventive treatment: The EMBRACE study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 658-671, March 2026.
Abstract Objective To evaluate the effect of erenumab treatment beyond monthly migraine days in patients with high‐frequency episodic migraine who did not respond to at least one previous migraine preventive treatment. Background Reduction in monthly migraine days has been the efficacy standard for migraine preventive treatments; however, it does not ...
Gabriel Paiva da Silva Lima, Renata Rao, Gyöngyi Szabó, Sebastian Szklener, Cristina Tassorelli, Marcin Nastaj, Denise E. Chou, Ani C. Khodavirdi, Mahan Chehrenama, Yineng Zhu, Ajay K. Bhatia, David W. Dodick   +11 more
wiley   +1 more source

Effects of Heating, Pelleting, and Feed Matrix on Apparent Concentrations of Cereal Ergot Alkaloids in Relation to Growth Performance and Welfare Parameters of Backgrounding Beef Steers

Toxins, 2022
As the contamination of cereal grains with ergot has been increasing in Western Canada, studies were undertaken to evaluate the impacts of heating (60, 80, 120, or 190 °C) alone or in combination with pelleting on concentrations of ergot alkaloids ...
Kim Stanford, Karen S. Schwartzkopf-Genswein, Daniela M. Meléndez, Skyler Ngo, Michael Harding, Tim A. McAllister, Dian Schatzmayr, Mary Lou Swift, Barry Blakley, Gabriel O. Ribeiro   +9 more
doaj   +1 more source

Headache in individuals undergoing hormone therapy for gender transition: A cross‐sectional, observational study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 725-732, March 2026.
Abstract Objective To assess the prevalence, frequency, and characteristics of headache disorders in transgender individuals receiving gender‐affirming hormone therapy (GAHT), and to explore the relationship between GAHT and headache pathophysiology.
Lucia Jimena Zavala, Andreina Gil Ramirez, Kjersti Grøtta Vetvik, Rigmor Højland Jensen, Anders Hougaard   +4 more
wiley   +1 more source

Ergotamine/Caffeine Overdose in a Female Suffering From Migraine Headache: A Case Report [PDF]

Pharmaceutical and Biomedical Research
Background: Ergotamine is a very common antimigraine and is widely used in the management of headaches such as cluster and acute migraines. However, Ergotamine poisoning is an infrequent condition, and there are very few cases reported.
Amir Hasan Farzaneh, Navid Khosravi
doaj