Results 71 to 80 of about 1,659,749 (358)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Agronomy, 2022 Activated water irrigation has been widely investigated as an effective production increasing measure. However, the response of activated water irrigation in plant growth and water use efficiency (WUE) with the irrigation amount is not well understood ...
Huan Wang, Jun Fan, Wei Fu
doaj +1 more source
Synthetic versus biological mesh-related erosion after laparoscopic ventral mesh rectopexy. A systematic review [PDF]
, 2017 Purpose: This review reports the incidence of mesh-related erosion after ventral mesh rectopexy to determine whether any difference exists in the erosion rate between synthetic and biological mesh. Methods: A systematic search of the MEDLINE and the Ovid
Balla, Andrea +5 more
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Circulation Research, 2019 The mechanisms that underlie superficial erosion, a cause of coronary thrombosis distinct from plaque rupture, have garnered recent interest. In an era of improved control of traditional risk factors, such as LDL (low-density lipoprotein), plaque erosion
P. Libby +3 more
semanticscholar +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
, 2020 Mediterranean environments are especially susceptible to soil erosion and to inappropriate soil management, leading to accelerated soil loss. Sustainable Land Management (SLM) practices (such as reduced tillage, no-tillage, cover crops, etc.,) have the ...
M. Martínez‐Mena +7 more
semanticscholar +1 more source
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Numerical Simulation on Shoreline Change in Western Region of Badung Regency, Bali, Indonesia [PDF]
, 2014 Shoreline change is considered the most dynamic processes in coastal region. Coastal erosion is a global problem where 70% beaches around the world are recessional. Almost all coastal area in Bali is potential to suffer from erosion.
Asai, K. (Koji) +1 more
core +2 more sources
Sediment flow paths and associated organic carbon dynamics across a Mediterranean catchment [PDF]
Hydrology and Earth System Sciences, 2015 Terrestrial sedimentation buries large amounts of organic carbon (OC) annually, contributing to the terrestrial carbon sink. The temporal significance of this sink will strongly depend on the attributes of the depositional environment, but also on the ...
C. Boix-Fayos +5 more
doaj +1 more source