Results 41 to 50 of about 5,593 (170)

Alcohol consumption is associated with an increased risk of erosive esophagitis and Barrett's epithelium in Japanese men

BMC Gastroenterology, 2008
Background Evidence regarding the association between alcohol consumption and the gastro-esophageal reflux disease (GERD) spectrum has been conflicting.
Goto Ayumu, Takahashi Hirokazu, Yoneda Masato, Fujita Koji, Yoneda Kyoko, Hosono Kunihiro, Endo Hiroki, Mawatari Hironori, Iida Hiroshi, Inamori Masahiko, Akiyama Tomoyuki, Abe Yasunobu, Kobayashi Noritoshi, Kubota Kensuke, Saito Satoru, Nakajima Atsushi   +15 more
doaj   +1 more source

Eosinophilic Esophagitis in Children: Clinical Cases

Кубанский научный медицинский вестник, 2022
Background. Eosinophilic esophagitis (Ee) is a chronic immune-mediated disease of the esophagus, which is characterized by symptoms of esophageal dysfunction and marked eosinophilic infiltration of the mucous membrane (MM) of the organ.
A. V. Burlutskaya, A. V. Statova, O. V. Dolbneva, I. I. Borlakova, J. V. Pisotskaya, D. V. Ustyuzhanina   +5 more
doaj   +1 more source

Single‐Cell Profiling Links T‐Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children

Allergy, EarlyView.
Active EoE is associated with more and deeper epithelial eosinophil, mast cell, and T cell infiltration; inactive EoE resembles controls. During remission, PPI treatment leaves more tissue resident CD3+ T‐cells than TS. In active EoE, TH2 cells, IL‐10hi Tregs, and CD8+ cytotoxic T cells are enriched, while TH17 cells are relatively depleted.
Hannes Hoelz, Matthias Tobias Warkotsch, Simon Buehler, Tim Faro, Sabrina Wagner, Valeriia Andrieieva, Alisia Beckmann, Anja Jurk, Marie‐Luise Frank, Guido Piontek, Kolja Siebert, Sebastian Jarosch, Sibylle Koletzko, Helga Paula Török, Christoph Walz, Martina Rudelius, Katja Steiger, Dirk Busch, Tobias Schwerd   +18 more
wiley   +1 more source

Clinical trial: The Effect on Intragastric pH and Pharmacokinetics of the PCAB Linaprazan Glurate in Healthy Subjects After Repeat‐Dose Administration for up to 14 Days

Alimentary Pharmacology &Therapeutics, EarlyView.
In this Phase 1 study, linaprazan glurate (LG) demonstrated rapid onset of intragastric acid suppression, achieving a pH > 4 within 10 to 60 min, and maintained pH control, with a 24‐h pH > 4 holding time ratio above 95% at 50 mg and 75 mg twice‐daily doses. AUC and Cmax of linaprazan, the main metabolite of LG, increased in proportion to LG dose.
Kajsa Larsson, Kjell Andersson, Gunilla Huledal, Jouni Junnila, Kristofer Katkits Nilsson, Elham Yektaei, Matjaž Fležar, Peter Unge   +7 more
wiley   +1 more source

Management of Asymptomatic Erosive Esophagitis: An E-Mail Survey of Physician's Opinions

Gut and Liver, 2013
Background/AimsThe management of asymptomatic erosive esophagitis is controversial. We surveyed physicians' opinions on asymptomatic erosive esophagitis using e-mail.Methods : All members of the Korean Society of Neurogastro-enterology and Motility were ...
doaj   +1 more source

The TOP‐GERD Trial: Comparative Efficacy of Tegoprazan Versus Pantoprazole in the Treatment of Erosive Oesophagitis in a Non‐Asian Population

Alimentary Pharmacology &Therapeutics, EarlyView.
In this randomized, double‐blind trial in Mexican adults with erosive oesophagitis, tegoprazan did not significantly improve the primary 4‐week ITT healing endpoint versus pantoprazole (88.9% vs. 79.4%; p = 0.33), but produced faster symptom improvement. Encouraging per‐protocol and severe‐oesophagitis findings warrant confirmation.
José M. Remes‐Troche, Luis Raúl Valdovinos‐García, C. Prakash Gyawali, José Luis Vargas‐Basurto, Carlos Alberto Reyes‐Medina, Gisselle Vanessa González‐Hernández, A. Rafael Bernal Mendez, H. H. Barragán Cordova, Pablo Thomas‐Dupont, Peter Grube‐Pagola   +9 more
wiley   +1 more source

Maior prevalência de obesidade na doença do refluxo gastroesofagiano erosiva Higher prevalence of obesity in erosive gastroesophageal reflux disease

Arquivos de Gastroenterologia, 2009
CONTEXTO: Existe uma noção geral de que indivíduos obesos desenvolvem mais freqüentemente a doença do refluxo gastroesofagiano, sendo a orientação de perder peso parte integrante do seu tratamento. Entretanto, uma base científica para esta associação não
Beatriz N. Biccas, Eponina Maria Oliveira Lemme, Luiz J. Abrahão Jr., Gustavo Cálcena Aguero, Ângela Alvariz, Rosana Bihari Schechter   +5 more
doaj   +1 more source

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

The FEBS Journal, EarlyView.
Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa, Meng‐Lay Lin, Stuart A. C. McDonald   +2 more
wiley   +1 more source

Association of Mean Nocturnal Baseline Impedance and AFS EGJ Grading With AET‐Defined Reflux Burden in Korean Patients

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Diagnosing gastroesophageal reflux disease (GERD) is challenging in borderline acid exposure time (AET). The Lyon Consensus 2.0 defines AET ≥ 6% as pathological reflux; however, East Asian standards often apply a 4% threshold, creating a diagnostic gray zone.
Ye‐Rin Chae, Ga Hee Kim, Ji Soo Moon, Jin Won Chang, Ji Hoon Yoon, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee   +9 more
wiley   +1 more source

Third Space Endoscopic Therapies for Benign Motility Disorders: A Narrative Review

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives To review the evidence base, evolution, outcomes, adverse events (AEs), and management for third‐space endoscopy (TSE) procedures for management of benign motility disorders. Methods This review examines TSE procedures for motility disorders, reviewing the current available techniques, success, outcomes, and long‐term outcomes from ...
Sanjana Bhagwat, Amol Bapaye
wiley   +1 more source