Results 31 to 40 of about 43,945 (232)

Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients—A Single‐Institution Retrospective Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab, a CD19xCD3 bispecific T‐cell engager, has become standard therapy for children with de novo B‐cell acute lymphoblastic leukemia (B‐ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients.
Julia M. Hurley, Ryleigh Krueger, Kellie Joyce, James Stanley, Mary Waskerwitz‐Freyer, Marielle Klunder, David J. Hoogstra   +6 more
wiley   +1 more source

Odd but Error-Free FastTwoSum: More General Conditions for FastTwoSum as an Error-Free Transformation for Faithful Rounding Modes

CoRR
This paper proposes sufficient, yet more general conditions for applying FastTwoSum as an error-free transformation (EFT) under all faithful rounding modes. Additionally, it also identifies guarantees tailored to round-to-odd for establishing FastTwoSum as an EFT. This paper also describes a floating-point splitting tailored for round-to-odd that is an
Sehyeok Park, Jay P. Lim, Santosh Nagarakatte   +2 more
openaire   +2 more sources

An Error-Free Transformation for Matrix Multiplication with Reproducible Algorithms and Divide and Conquer Methods

Journal of Physics: Conference Series, 2020
Abstract This paper discusses accurate numerical algorithms for matrix multiplication. Matrix multiplication is a basic and important problem in numerical linear algebra. Numerical computations using floating-point arithmetic can be quickly performed on existing computers.
openaire   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development and validation of an automated and marker-free CT-based spatial analysis method (CTSA) for assessment of femoral hip implant migration In vitro accuracy and precision comparable to that of radiostereometric analysis (RSA)

Acta Orthopaedica, 2016
Background and purpose — We developed a marker-free automated CT-based spatial analysis (CTSA) method to detect stem-bone migration in consecutive CT datasets and assessed the accuracy and precision in vitro.
Thierry Scheerlinck, Mathias Polfliet, Rudi Deklerck, Gert Van Gompel, Nico Buls, Jef Vandemeulebroucke   +5 more
doaj   +1 more source

Error‐free computation of 8‐point discrete cosine transform based on the Loeffler factorisation and algebraic integers

IET Signal Processing, 2016
An 8‐point discrete cosine transform (DCT) fast algorithm based on the Loeffler DCT factorisation and algebraic integer (AI) representation is proposed. The proposed algorithm is an error‐free implementation of the Loeffler algorithm and it is capable of computing the 8‐point DCT multiplierlessly. Decoding architectures are also proposed for mapping AI
Diego F. G. Coelho, Renato J. Cintra, Sunera Kulasekera, Arjuna Madanayake, Vassil S. Dimitrov   +4 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source