Results 81 to 90 of about 2,825,138 (268)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

INCRIMINAREA CONȘTIINȚEI ÎN BUDHISMUL YOGACARA. CONDIȚIA IGNORANT-DUREROASĂ A OMULUI ȘI ORIGINEA SA ÎN CONȘTIINȚĂ

open access: yesAnalele Universităţii "Dunărea de Jos" din Galaţi. Fascicula XIX, Istorie
Even though, in Mahyna Buddhism, ultimate reality is sometimes considered to have a conscious nature, the most common Buddhist approach to consciousness is rather a phenomenal one.
Ovidiu Cristian Nedu
doaj   +1 more source

Typical Lexical Errors in Russian Speech of Greek Students (Level A2)

open access: yesНаучный диалог, 2018
Different approaches to the interpretation of the concept “error in speech in a non-native language” are analyzed: psychological, psycholinguistic, linguistic, methodical.
N. L. Fedotova, (. Z. Stamboleva
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

English Language Error Analysis of the Written Texts Produced by Ukrainian Learners: Data Collection

open access: yesCognitive Studies | Études cognitives, 2015
English Language Error Analysis of the Written Texts Produced by Ukrainian Learners: Data Collection Recently, the studies of second language acquisition have tended to focus on learners errors as they help to predict the difficulties involved in ...
Lessia Mykolayivna Kotsyuk
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Hilbert’s Error? [PDF]

open access: yesThe Mathematical Intelligencer, 2018
It is well known that a center of a given circle cannot be constructed using only a straightedge and that this was proven by David Hilbert. Still it is not so clear what kind of object is proven to be non-existing. We analyze different attempts to define a geometric construction appearing in the literature and observe that none of them is really ...
openaire   +3 more sources

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