Results 81 to 90 of about 10,005,121 (298)
Acta Médica Costarricense, 2008 En todas las actuaciones de los seres humanos, los errores son una realidad innegable. Por ser el ejercicio de la medicina algo que afecta directamente a las personas, este tema es uno de los más controvertidos, tanto en el nivel profesional como en los medios de comunicación, que siempre están ávidos de noticias impactantes y las destacan con ...
openaire +4 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Environmental Research: EnergyRuntime and memory requirements for typical formulations of energy system models increase non-linearly with resolution, computationally constraining large-scale models despite state-of-the-art solvers and hardware. This scaling paradigm requires omission
Anna F Jacobson +2 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
L'error en els aparells com a possibilitat estètica
Artnodes, 2012 L'error sembla que és el que s'interposa entre l'ésser ideal i el real. Un esdeveniment, un No-ésser que transforma i deforma l'Ésser. En les tècniques, tecnologies, suports i mitjans audiovisuals es mira de suprimir; tanmateix, hi ha una possibilitat ...
Alejandro Schianchi
doaj +1 more source
Concatenation of Error Avoiding with Error Correcting Quantum Codes for Correlated Noise Models
, 2010 We study the performance of simple error correcting and error avoiding quantum codes together with their concatenation for correlated noise models. Specifically, we consider two error models: i) a bit-flip (phase-flip) noisy Markovian memory channel ...
Cafaro, Carlo, Mancini, Stefano
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Известия высших учебных заведений: Нефть и газ, 2016 This article considers the problems of estimation of the structural model verification based on the results of the well horizontal section drilling. The method of estimation by standard criteria of the structure confirmation is presented as well as the ...
R. M. Bembel, I. A. Schetinin
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