Results 91 to 100 of about 7,381,056 (283)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A case study of fractional-order varicella virus model to nonlinear dynamics strategy for control and prevalence

Nonlinear Engineering
The purpose of this work is to construct and evaluate a dynamical susceptible–vaccinated–infected–recovered model for the propagation of the varicella virus in Jordan using existing epidemiological data.
Nisar Kottakkaran Sooppy, Farman Muhammad, Ghannam Manal, Hincal Evren, Sambas Aceng   +4 more
doaj   +1 more source

Assessment of Level-3 Gridded Global Precipitation Mission (GPM) Products Over Oceans

Remote Sensing, 2019
The performance of Level-3 gridded Global Precipitation Mission (GPM)-based precipitation products (IMERG, Integrated Multi-satellite Retrievals for GPM) is assessed against two references over oceans: the OceanRAIN dataset, derived from oceanic ...
Sana Khan, Viviana Maggioni
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Analysis of students' errors in solving quadratic equation word problems based on Watson's criteria

Journal Focus Action of Research Mathematic
This research is motivated by the phenomenon of low student ability in solving word problems in mathematics, indicating significant challenges in understanding and applying mathematical concepts in real-life contexts. The aim of this study is to describe
Azin Taufik, Anggar Titis Prayitno, Tika Nuanatul Mufida   +2 more
doaj   +1 more source

Estimation with Norm Regularization [PDF]

, 2015
Analysis of non-asymptotic estimation error and structured statistical recovery based on norm regularized regression, such as Lasso, needs to consider four aspects: the norm, the loss function, the design matrix, and the noise model.
Banerjee, Arindam, Chen, Sheng, Fazayeli, Farideh, Sivakumar, Vidyashankar   +3 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Method for Designing FIR Filters with Arbitrary Magnitude Characteristic Used for Modeling Human Audiogram

Advances in Electrical and Computer Engineering, 2012
This paper presents an iterative method for designing FIR filters that implement arbitrary magnitude characteristics, defined by the user through a set of frequency-magnitude points (frequency samples).
SZOPOS, E., NEAG, M., SARACUT, I., HEDESIU, H., FESTILA, L.   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Error analysis of surface temperature measurement by thermocouple

Nihon Kikai Gakkai ronbunshu, 2018
In surface temperature measurement by thermocouple, measurement error was quantitatively investigated when the temperature measuring junction was adhered to the surface and a part of the lead wire was placed on the isothermal surface.
Hajime NAKAMURA
doaj   +1 more source