Results 151 to 160 of about 32,468,808 (365)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Analysis of students' errors in solving quadratic equation word problems based on Watson's criteria

open access: yesJournal Focus Action of Research Mathematic
This research is motivated by the phenomenon of low student ability in solving word problems in mathematics, indicating significant challenges in understanding and applying mathematical concepts in real-life contexts. The aim of this study is to describe
Azin Taufik   +2 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Benchmarking the Non-Paraxial Beam Propagation Method for Deep-Tissue Microscopy

open access: yesIEEE Access
This study evaluates the accuracy and computational efficiency of the Beam Propagation Method (BPM) for modeling light propagation in microscopy of biological tissue.
Praveen Kalarickel Ramakrishnan   +2 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Dynamic Energy Sparse Self-Attention Based on Informer for Remaining Useful Life of Rolling Bearings

open access: yesIEEE Access
Predicting the remaining useful life of rolling bearings presents significant challenges due to their nonstationary degradation patterns. Conventional methods struggle with long sequences and are strongly dependent on manual feature extraction, which can
Cheng Shi   +4 more
doaj   +1 more source

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