Results 81 to 90 of about 1,951,890 (275)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Perturbation of error bounds

Mathematical Programming, 2017
Our aim in the current article is to extend the developments in Kruger, Ngai & Th ra, SIAM J. Optim. 20(6), 3280-3296 (2010) and, more precisely, to characterize, in the Banach space setting, the stability of the local and global error bound property of inequalities determined by proper lower semicontinuous under data perturbations. We propose new
A. Y. Kruger, M. A. López, M. A. Théra
openaire   +5 more sources

Exact, approximate solutions and error bounds for coupled implicit systems of partial differential equations

International Journal of Mathematics and Mathematical Sciences, 1992
In this paper coupled implicit initial-boundary value systems of second order partial differential equations are considered. Given a finite domain and an admissible error ϵ an analytic approximate solution whose error is upper bounded by ϵ in the given ...
Lucas Jódar
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

An Error Bound for Low Order Approximation of Dynamical Systems Subjected to Initial Conditions

Trends in Computational and Applied Mathematics, 2018
In recent years, a great effort has been taken focused on the development of reduced order modeling techniques of dynamical systems. This necessity is pushed by the requirement for efficient numerical techniques for simulations of dynamical systems ...
Gabriel Pedro Ramos Maciel, Roberto Spinola Barbosa   +1 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Error Bounds forDiscrete Geometric Approach

Computer Modeling in Engineering & Sciences, 2010
Electromagnetic problems spatially discretized by the so called Discrete Geometric Approach are considered, where Discrete Counterparts of Constitutive Relations are discretized within an Energetic Approach. Pairs of oriented dual grids are considered in which the primal grid is composed of (oblique) parallelepipeds, (oblique) triangular prisms and ...
CODECASA, LORENZO, F. Trevisan
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

δ-perturbation of bilevel optimization problems: An error bound analysis

Operations Research Perspectives
In this paper, we analyze a perturbed formulation of bilevel optimization problems, which we refer to as δ-perturbed formulation. The δ-perturbed formulation allows to handle the lower level optimization problem efficiently when there are multiple lower ...
Margarita Antoniou, Ankur Sinha, Gregor Papa   +2 more
doaj   +1 more source