Results 51 to 60 of about 6,085,361 (298)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Experimental Characterization, Modeling, and Analysis of Crosstalk in a Quantum Computer

IEEE Transactions on Quantum Engineering, 2020
In this article, we present the experimental characterization of crosstalk in quantum information processor using idle tomography and simultaneous randomized benchmarking.
Abdullah Ash- Saki, Mahabubul Alam, Swaroop Ghosh   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Multilayer cycle benchmarking for high-accuracy error characterization

Physical Review Research
Accurate noise characterization is essential for reliable quantum computation. Effective Pauli noise models have emerged as powerful tools, offering a detailed description of the error processes with a manageable number of parameters, which guarantees ...
Alessio Calzona, Miha Papič, Pedro Figueroa-Romero, Adrian Auer   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A method for multiplex gene synthesis employing error correction based on expression. [PDF]

PLoS ONE, 2015
Our ability to engineer organisms with new biosynthetic pathways and genetic circuits is limited by the availability of protein characterization data and the cost of synthetic DNA.
Timothy H-C Hsiau, David Sukovich, Phillip Elms, Robin N Prince, Tobias Strittmatter, Paul Ruan, Bo Curry, Paige Anderson, Jeff Sampson, J Christopher Anderson   +9 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Range Information Characterization of the Hokuyo UST-20LX LIDAR Sensor

Photonics, 2018
This paper presents a study on the data measurements that the Hokuyo UST-20LX Laser Rangefinder produces, which compiles into an overall characterization of the LiDAR sensor relative to indoor environments.
Matthew A. Cooper, John F. Raquet, Rick Patton   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Scalable Noise Characterization of Syndrome-Extraction Circuits with Averaged Circuit Eigenvalue Sampling

PRX Quantum
Characterizing the performance of noisy quantum circuits is central to the production of prototype quantum computers and can enable improved quantum error correction that exploits noise biases identified in a quantum device.
Evan T. Hockings, Andrew C. Doherty, Robin Harper   +2 more
doaj   +1 more source