Results 141 to 150 of about 5,234,415 (293)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Error-detecting solid codes

CoRR
2 ...
openaire   +2 more sources

Artificial intelligence-based speech error detection to differentiate primary progressive aphasia variants. [PDF]

Brain Commun
Vonk JMJ, Lian J, Kurteff GL, Cho CJ, Antonicelli G, Ezzes Z, Wauters LD, Keegan-Rodewald W, Rodriguez DA, Dronkers N, Henry ML, Miller ZA, Mandelli ML, Anumanchipalli GK, Gorno-Tempini ML.   +14 more
europepmc   +1 more source

Error detection and correction in intracortical brain-machine interfaces controlling two finger groups. [PDF]

J Neural Eng, 2023
Wallace DM, Benyamini M, Nason-Tomaszewski SR, Costello JT, Cubillos LH, Mender MJ, Temmar H, Willsey MS, Patil PG, Chestek CA, Zacksenhouse M.   +10 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Low-cost head-mounted camera system for medication-error detection. [PDF]

HardwareX
Nsumba S, Kaitesi J, Namutosi D, Mugagga PK, Nakatumba-Nabende J, Nabende P.   +5 more
europepmc   +1 more source

High-Speed Hardware Architecture Based on Error Detection for KECCAK. [PDF]

Micromachines (Basel), 2023
Mestiri H, Barraj I.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From zero-shot to fine-tuning: optimize large language models for error detection of ultrasound reports. [PDF]

Insights Imaging
Lai M, Zhang J, Lv Y, Hou C, Wang C, Li F, Xu S, Du M, Wei M, Xu D, Sun L.   +10 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source