Results 51 to 60 of about 1,205,694 (316)
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Correcting the Autocorrect: Context-Aware Typographical Error Correction via Training Data Augmentation [PDF]
arXiv, 2020 In this paper, we explore the artificial generation of typographical errors based on real-world statistics. We first draw on a small set of annotated data to compute spelling error statistics. These are then invoked to introduce errors into substantially larger corpora.
arxiv
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
Functional Diagnosis of Digital State Automation Networks
Известия высших учебных заведений России: Радиоэлектроника, 2018 The problem of functional diagnosis of digital devices forming a network of state automata is considered. This task for the network components is supposed to be solved, and the corresponding diagnostic devices for them are provided.
I. V. Bystrova, B. P. Podkopaev
doaj +1 more source
Silent error detection in numerical time-stepping schemes [PDF]
The International Journal of High Performance Computing
Applications, 29(4), 2015, 2013 Errors due to hardware or low level software problems, if detected, can be fixed by various schemes, such as recomputation from a checkpoint. Silent errors are errors in application state that have escaped low-level error detection. At extreme scale, where machines can perform astronomically many operations per second, silent errors threaten the ...
arxiv +1 more source
Detecting Errors in Spreadsheets
, 2008 The paper presents two complementary strategies for identifying errors in spreadsheet programs. The strategies presented are grounded on the assumption that spreadsheets are software, albeit of a different nature than conventional procedural software. Correspondingly, strategies for identifying errors have to take into account the inherent properties ...
Ayalew, Yirsaw +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
Error detection and unit conversion [PDF]
IEEE Engineering in Medicine and Biology Magazine, 2009 The article discusses the accuracy mathematical modeling languages (MML) for biomedicine, for example in cardiac electrophysiology. Unit balance checking is showed that it can be automated. The implemented example is JSim (http://www.physiome.org/ jsim/), which is general and can be applied to other systems in which units can be specified and checked ...
James B. Bassingthwaighte +2 more
openaire +3 more sources