Results 71 to 80 of about 1,041,335 (309)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The human gut microbiome across the life course
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Combined Error Detection and Error-Correction [PDF]
This chapter is concerned with the design of codes and systems for combined error detection and correction, primarily aimed at applications featuring retransmission of data packets which have not been decoded correctly. Several such hybrid automatic request, HARQ, systems are described including a novel system variation which uses a retransmission ...
Martin Tomlinson +4 more
openaire +1 more source
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Receiver Multiuser Diversity Aided Multi-Stage MMSE Multiuser Detection for DS-CDMA and SDMA Systems Employing I-Q Modulation [PDF]
The so-called receiver multiuser diversity aided multistage minimum mean-square error multiuser detector (RMD/MS-MMSE MUD), which was proposed previously by the author, is investigated in the context of the direct-sequence code-division multiple-access ...
Yang, Lie-Liang, Lie-Liang Yang
core +1 more source
Error Detection in a Large-Scale Lexical Taxonomy
Knowledge base (KB) is an important aspect in artificial intelligence. One significant challenge faced by KB construction is that it contains many noises, which prevent its effective usage.
Yinan An, Sifan Liu, Hongzhi Wang
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Manipulations and Errors, Detection and Localization [PDF]
We investigate the possibility of using error correcting codes in digital signatures. A scheme combining one way functions and a MDS code is presented and analyzed. We then study an attack upon this scheme and upon more general ones called "random knapsack schemes" involving a linear combination ?i T(xi,i) of the message elements xi.
Philippe Godlewski, Paul Camion
openaire +1 more source
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source

