Results 51 to 60 of about 601,840 (265)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

On optimal quadrature formulae

open access: yesJournal of Inequalities and Applications, 2000
A procedure to construct quadrature formulae which are exact for solutions of linear differential equations and are optimal in the sense of Sard is discussed. We give necessary and sufficient conditions under which such formulae do exist.
Lanzara Flavia
doaj  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Convergence estimates for the acoustic scattering problem approximated by NURBS

open access: yesComputer Assisted Methods in Engineering and Science, 2017
The paper contains some estimates of an approximation to the solution of the problem of acoustic waves's scattering by an elastic obstacle in two dimensions.
Andrzej Karafiat
doaj   +1 more source

Analytic Error Estimates [PDF]

open access: yesThe Astrophysical Journal, 1995
13 pages ...
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A highly efficient spectral-Galerkin method based on tensor product for fourth-order Steklov equation with boundary eigenvalue

open access: yesJournal of Inequalities and Applications, 2016
In this study, a highly efficient spectral-Galerkin method is posed for the fourth-order Steklov equation with boundary eigenvalue. By making use of the spectral theory of compact operators and the error formulas of projective operators, we first obtain ...
Jing An, Hai Bi, Zhendong Luo
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

General Local Convergence Theorems about the Picard Iteration in Arbitrary Normed Fields with Applications to Super–Halley Method for Multiple Polynomial Zeros

open access: yesMathematics, 2020
In this paper, we prove two general convergence theorems with error estimates that give sufficient conditions to guarantee the local convergence of the Picard iteration in arbitrary normed fields. Thus, we provide a unified approach for investigating the
Stoil I. Ivanov
doaj   +1 more source

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