Results 71 to 80 of about 9,541,376 (284)
Earth and Space ScienceAtmospheric state analysis is a difficult scientific problem but essential for atmospheric sciences. Data assimilation can generate accurate analyses by integrating information on the atmospheric state using probability density functions (PDFs), where ...
Toshiyuki Ishibashi
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Impact of toroidal-field-coil generated error field over ADITYA Ohmic breakdown and start-up
Nuclear FusionThe conventional Ohmic plasma breakdown and current ramp-up in the ADITYA tokamak have been investigated over a wide range of input parameters to understand the error field generated by the toroidal field (TF) coils.
S. Purohit +13 more
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
AIP Advances, 2020 Effects of the equilibrium plasma flow on the error field-driven tearing mode are investigated in a two-dimensional resistive magnetohydrodynamics model.
Bang-Feng Zhang, Xian-Qu Wang
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Toroidal modeling of the effect of resonant q95 on n = 1 error field penetration in EAST
Nuclear FusionThe plasma response to the n = 1 resonant magnetic perturbation in EAST has been systematically investigated using the MARS-F/Q codes, focusing on the roles of q _95 and $\beta_\mathrm N$ in error field penetration.
Cheng Ye +6 more
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User-Friendly Locations of Error Messages in Web Forms: An Eye Tracking Study
Journal of Eye Movement Research, 2016 Error messages presented to users are one of the most important elements of Web forms. Error messages are embedded in different parts of the forms available on the Internet and presented in various formats.
Yavuz Inal
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Error report for Wessel (2018)
DECISION AND RECOMMENDATION Wessel (2018) “Prepotent motor activity and inhibitory control demands in different variants of the go/no-go paradigm” was determined to contain Minor Errors. That is, errors that have the benefit of being detectable thanks to
ERROR
core +1 more source