Results 101 to 110 of about 1,049,459 (316)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Error Estimates for a Class of Elliptic Optimal Control Problems
, 2017 In this article, functional type a posteriori error estimates are presented for a certain class of optimal control problems with elliptic partial differential equation constraints.
Mali, Olli
core +1 more source
Study on Error Pattern of Consonant of Children with Functional Dysarthria
康复学报, 2015 Objective:To study the distribution characteristics, error pattern and acquistion features of disordered consonants of children with functional dysarthria, so as to provide the theoretical guidance for the design of pronunciation rehabilitation programs ...
Zhihong DU +4 more
doaj
Error Models of the Analog to Digital Converters
Measurement Science Review, 2014 Error models of the Analog to Digital Converters describe metrological properties of the signal conversion from analog to digital domain in a concise form using few dominant error parameters.
Michaeli Linus, Šaliga Ján
doaj +1 more source
An Overview of Robotics in Functional Neurosurgery
Indian Journal of Neurosurgery, 2019 Stereotactic techniques are used in a wide range of neurosurgical procedures. The procedures demand a high degree of spatial accuracy and minimal error.
Vikas Vazhayil +5 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Uncertainty Quantification of Complex Weather Dynamics Using a Novel Functional Autoregressive Model
MathematicsFunctional time series (FTS) modeling has emerged as a powerful framework for capturing complex temporal dependencies using the functional autoregressive models FAR(p, m) and FARX(p, m, τ). These functional models characterize the evolution of functional
Ismail Shah +3 more
doaj +1 more source
Black box systems identification with estimation
Revista Facultad de Ingeniería Universidad de Antioquia, 2014 In a black box system the internal parameters are not observables between input-output relationships. An approach is made knowing as estimation, based on the second probability moment. These results with a functional error and the innovation
María Teresa Zagceta Álvarez +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source