Results 51 to 60 of about 601,161 (266)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

A Comparison of Double Convex and Double Concave Improved Nyquist Filters

open access: yesAdvances in Electrical and Computer Engineering, 2010
This paper presents a comparative analysis of two families of improved Nyquist filters with a piece-wise parabolic frequency characteristic. Their construction is based on a novel approach and produces ISI-free pulses that shows comparable or better ISI ...
ALEXANDRU, N. D., ALEXANDRU, M. L.
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Probability Inequalities and Errors in Classification

open access: yesThe Annals of Statistics, 1974
Let $X$ and $Y$ be two $p \times 1$ random vectors distributed according to a normal distribution with respective mean vectors $\mu$ and $a\mu$ and covariance matrix $\begin{pmatrix}I_p & \rho I_p \\ \rho I_p & I_p\end{pmatrix}.$ Let $S$ be a random $p \times p$ matrix distributed as the Wishart distribution $W_p(I_p, r)$, independently of $X$ and $Y$.
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Digital Communication Systems Based on Three-Dimensional Chaotic Attractors

open access: yesIEEE Access, 2019
In this paper, we propose a methodology to design chaos-based communication systems, which exploits the topological structure of 3-D chaotic attractors. The first step consists in defining a proper partition of a Poincaré section of the attractor
Carlos E. C. Souza   +2 more
doaj   +1 more source

Searching with known error probability

open access: yesTheoretical Computer Science, 1989
We study the problem of interactive searching in a set of numbers using comparison queries, under the assumption that each answer can be erroneous with a constant probability p and that a given reliability ...
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Ferroelectric Transistor-Based Synaptic Crossbar Arrays: The Impact of Ferroelectric Thickness and Device-Circuit Interactions

open access: yesIEEE Journal on Exploratory Solid-State Computational Devices and Circuits
Ferroelectric transistors (FeFETs)-based crossbar arrays have shown immense promise for computing-in-memory (CiM) architectures targeted for neural accelerator designs.
Chunguang Wang, Sumeet Kumar Gupta
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

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