Results 41 to 50 of about 26,065 (243)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Striatal prediction error modulates cortical coupling [PDF]

, 2010
Both perceptual inference and motor responses are shaped by learned probabilities. For example, stimulus-induced responses in sensory cortices and preparatory activity in premotor cortex reflect how (un)expected a stimulus is.
Ouden, H.E.M. den, Roiser, J., den Ouden, H.E.M., den Ouden, H E M, Daunizeau, J, Friston, K J, J. Roiser, K. E. Stephan, Stephan, K.E., H. E. M. den Ouden, K. J. Friston, Stephan, K E, J. Daunizeau, Daunizeau, J., Friston, K.J., Roiser, J   +15 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Irregular Variable Length Coding [PDF]

, 2007
In this thesis, we introduce Irregular Variable Length Coding (IrVLC) and investigate its applications, characteristics and performance in the context of digital multimedia broadcast telecommunications.
Maunder, R. G., Maunder, Robert G
core  

Adaptive minimum symbol error rate beamforming assisted detection for quadrature amplitude modulation [PDF]

, 2008
—We consider beamforming assisted detection for multiple antenna aided multiuser systems that employ the bandwidth efficient quadrature amplitude modulation scheme.
Chen, Sheng, Livingstone, A., Hanzo, Lajos, Du, H.-Q.   +3 more
core   +1 more source

Index Coding with Multiple Interpretations [PDF]

, 2022
The index coding problem consists of a system with a server and multiple receivers with different side information and demand sets, connected by a noiseless broadcast channel. The server knows the side information available to the receivers.
Costa, Max H. M., Max H. M. Costa, Pedrosa, Valéria G., Valéria G. Pedrosa   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Trade-offs between Error Exponents and Excess-Rate Exponents of Typical Slepian–Wolf Codes [PDF]

, 2021
Typical random codes (TRCs) in a communication scenario of source coding with side information in the decoder is the main subject of this work. We study the semi-deterministic code ensemble, which is a certain variant of the ordinary random binning code ...
Ran Tamir (Averbuch), Neri Merhav
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source