Results 121 to 130 of about 18,518,960 (329)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Inconsistent multiple testing corrections: The fallacy of using family-based error rates to make inferences about individual hypotheses

Methods in Psychology
During multiple testing, researchers often adjust their alpha level to control the familywise error rate for a statistical inference about a joint union alternative hypothesis (e.g., “H1,1 or H1,2”).
Mark Rubin
doaj   +1 more source

Familywise error rate control for block response-adaptive randomization. [PDF]

Stat Methods Med Res, 2023
Glimm E, Robertson DS.
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Impact of translational error‐induced and error‐free misfolding on the rate of protein evolution

Molecular Systems Biology, 2010
What determines the rate of protein evolution is a fundamental question in biology. Recent genomic studies revealed a surprisingly strong anticorrelation between the expression level of a protein and its rate of sequence evolution.
Jian‐Rong Yang, Shi‐Mei Zhuang, Jianzhi Zhang   +2 more
doaj   +1 more source

Small sample statistics for classification error rates I : error rate measurements

, 1995
Several methods (independent subsamples, leave-one-out, cross-validation, and bootstrapping) have been proposed for estimating the error rates of classifiers. The rationale behind the various estimators and the causes ofthe sometimes conflicting claims regarding their bias and precision are explored in this paper.
Martin, J. Kent, Hirschberg, D. S.
openaire   +2 more sources

Double symbol error rate and block error rate of MDPSK

Electronics Letters, 1991
The double symbol error rate (DSER) is calculated for an M-ary DPSK (MDPSK) system to show that double symbol errors are less likely to be produced when M ≥ 4 than for the binary case (M = 2) and that MDPSK with M ≥ 4 provides similar conditional SER (defined as the SER when the previous symbol decision was in error) when compared at the same SER value.
F. Adachi, T. Matsumoto
openaire   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

OFDM-NOMA Error Rate Reduction Using Direct Data Detection

IEEE Open Journal of the Communications Society
The direct data detection ( $D^{3}$ ) is proven to provide a significant error rate reduction for orthogonal multiple access (OMA) schemes because it does not directly depend on the estimated channel state information (CSI).
Tasneem Assaf, Arafat Al-Dweik, Anshul Pandey, Jean-Pierre Giacalone   +3 more
doaj   +1 more source