Results 141 to 150 of about 6,870,757 (231)

The ultimate forgery: A semiotic deconstruction of large language models as engines of simulated selfhood

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Information science rests on a compact: its mediating signs maintain a traceable relation to what they describe. Large language models (LLMs) break it architecturally, generating discourse that is statistically plausible yet epistemically ungrounded, while standard metrics (precision, recall, relevance) cannot detect the rupture.
Martin Thellefsen, Alon Friedman
wiley   +1 more source

Distinguishing different psychiatric disorders using DDx-PRS. [PDF]

Nat Genet
Peyrot WJ, Panagiotaropoulou G, Olde Loohuis LM, Adams MJ, Andreassen OA, Awasthi S, Forstner AJ, Ge T, McIntosh AM, Mitchell BL, Mullins N, O'Connell KS, Penninx BWJH, Posthuma D, Ripke S, Ruderfer DM, Uffelmann E, Vilhjalmsson BJ, Zhu Z, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Smoller JW, Price AL.   +23 more
europepmc   +1 more source

Electroconvulsive Therapy for Catatonia in Autistic and Non‐Autistic Patients: An Observational Study on Course, Efficacy, Aggression, and Self‐Injury Outcomes

Autism Research, EarlyView.
ABSTRACT Catatonia occurs disproportionately in autistic individuals and may respond to electroconvulsive therapy (ECT), yet prior reports suggest greater treatment burden in this population. We compared longitudinal ECT utilization, safety, and clinical outcomes between autistic and non‐autistic patients with catatonia.
Joshua Ryan Smith, Maria Bonnee, Sarah Marler, Seri Lim, D. Catherine Fuchs, Rafael Tamargo, Isaac Baldwin, Christopher Maley, Ashley VanHaverbeck, Courtney Hamilton, Timothy Adegoke, Haozheng Xu, Jinyuan Liu, Zachary J. Williams, Jo Ellen Wilson, James Luccarelli   +15 more
wiley   +1 more source

Day/night temperature fluctuations delay the high-temperature-induced decline in Cry1Ac endotoxin concentration in cotton squares. [PDF]

Front Plant Sci
Liu Y, Ou R, Gu Z, Gao W, Chen Y, Zhang X, Chen D.   +6 more
europepmc   +1 more source

Model‐informed optimal dose selection of golcadomide in combination with R‐CHOP in patients with previously untreated aggressive B‐cell lymphoma

British Journal of Clinical Pharmacology, EarlyView.
Aims Golcadomide is a potential first‐in‐class oral CELMoD™ agent for the treatment of lymphoma. This study aims to develop model‐informed drug development (MIDD) approaches to support optimal dose selection of golcadomide in combination with immunotherapy rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP) in alignment with ...
Xirong Zheng, Zhiling Yu, Mark Kaplan, Argyrios Gkasiamis, Akshay Sudhindra, Li Zhu, Manisha Lamba, Fan Wu   +7 more
wiley   +1 more source

AICO: Feature significance tests for supervised learning. [PDF]

Proc Natl Acad Sci U S A
Giesecke K, Horel E, Jirachotkulthorn C.
europepmc   +1 more source

Sustainability and Value Transitions: The Strategic Role of Cross‐Sectoral Interconnectedness and Transition Brokers

Business Strategy and the Environment, EarlyView.
ABSTRACT Climate economics is undergoing rapid transformation, reconfiguring the foundations of sustainability transitions. This study develops a systems‐based perspective that foregrounds the strategic role of cross‐sectoral interconnectedness and transition brokers in shaping these transitions.
Ionna Trofimova‐Elliot
wiley   +1 more source

ModBind_dG: A simulation-based absolute predictor of free energy of binding based on population reweighting. [PDF]

Proc Natl Acad Sci U S A
Sinko W, Mertz B, Terada Y, Kimura SR.
europepmc   +1 more source

Do You Feel Like a Greenwasher? Analysing Environmental Management Practices Under Perceived Greenwashing by Managers

Business Strategy and the Environment, EarlyView.
ABSTRACT In recent years, escalating societal expectations for corporate environmental responsibility have intensified the scrutiny of sustainability initiatives. Consequently, organisations have adopted diverse environmental management practices (EMPs) to signal environmental commitment and bolster their sustainability profiles.
Hadeel Abualinin, Vera Ferrón Vílchez, Mohammad Khalil   +2 more
wiley   +1 more source

Tobacco Use Trajectories and Associated Changes in Biometrics and Sleep During the First 72 Weeks of Wearable Membership: Observational Cohort Study. [PDF]

JMIR Mhealth Uhealth
Curran DJ, Leota J, Hippel WV, Fielding F, Chapman CJ, Cohen JG, Presby DM, Jhunjhunwala R, Holmes KE, Grosicki GJ.   +9 more
europepmc   +1 more source