Results 161 to 170 of about 6,870,757 (231)
Large-scale simulation of coverage and error rate tradeoffs for cancer detection in cell-free DNA whole-genome sequencing. [PDF]
BioinformaticsChen LT, de Ridder J, Jager M.
europepmc +1 more source
Dynamic Calibration of DEM Simulations Using Rotating Drum Experiments Using the Mean Absolute Error
Chemie Ingenieur Technik, EarlyView.Calibrating DEM simulations is challenging due to unknown microscopic parameters. Rotating drum experiments are combined with image‐based analysis and Latin Hypercube Sampling (LHS). An area‐based Mean Absolute Error (MAE) enables reliable identification of optimal parameter sets.
Marius Hoffmann +2 more
wiley +1 more source
Estimating and Evaluating Roughness Length and Displacement Height in Heterogeneous Urban Environments. [PDF]
Boundary Layer MeteorolHorne JP, Pan Y, Davis KJ.
europepmc +1 more source
Assessment of Gibbs Free Energy Calculation in PI‐Controlled Heating
Chemie Ingenieur Technik, EarlyView.For description and control of chemical processes in lab or industry thermodynamic variable Gibbs free energy provides opportunity to compare and interpret phenomena, even on a quantitative level. In a case study for PI‐controlled heating, impacts on its limits from control delay until parameter quantization are highlighted and assessed.
Jannik Dutschke +4 more
wiley +1 more source
A Fast, Flexible Simulation Framework for Bayesian Adaptive Designs-The R Package BATSS. [PDF]
Pharm StatCouturier DL +4 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Cofetuzumab pelidotin (Cofe‐P) is an anti‐protein tyrosine kinase 7 (PTK7) antibody‐drug conjugate (ADC) being investigated for the treatment of adults with PTK7‐expressing, recurrent non‐small cell lung cancer (NSCLC). The first‐in‐human (FIH) trial demonstrated tolerability of dosages ≤ 2.8 mg/kg once every 3 weeks (Q3W) and ≤ 3.2 mg/kg Q2W ...
Carla Biesdorf +8 more
wiley +1 more source
Group Sequential Sample Size for Comparing Two Survival Probabilities at a Specific Time Point. [PDF]
Stat MedHalabi S, Liu L, Yu C, Wu Y.
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong +10 more
wiley +1 more source