Advanced Science, EarlyView.We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang +15 more
wiley +1 more source
Development and Evaluation of an Adaptive Penguin-Improved LSTM Model Integrating Natural Language Processing for Early Prediction of Pregnancy Syndrome Risks. [PDF]
Birth Defects ResWu Y.
europepmc +1 more source
Advances in Josephson Junction Materials and Processes Toward Practical Quantum Computing
Advanced Science, EarlyView.Emerging materials for quantum computing, including crystalline materials, two‐dimensional van der Waals materials, two‐dimensional electron gas systems, ferromagnets, and unconventional (e.g., d‐wave) superconductors, offer opportunities to engineer next‐generation Josephson junctions.
Hyunseong Kim +11 more
wiley +1 more source
Benchmarking the performance of large language models on medical genetics questions: a comparative evaluation of GPT-5.1, Gemini Pro 3, and Claude Opus 4.5. [PDF]
Front Med (Lausanne)Basdemirci M, Tassoker M.
europepmc +1 more source
Advanced Science, EarlyView.A carrier‐free peptide‐guided PSP@IR‐CF3 nanofiber system integrates PD‐L1 targeting and photothermal immunotherapy for enhanced cancer treatment. By revealing PTIT‐induced activation of the HSP70/AKT/mTOR pathway and incorporating mTOR inhibition, this strategy effectively overcomes therapeutic resistance and prevents tumor recurrence, providing a ...
Xinyu Zhang +11 more
wiley +1 more source
The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients. [PDF]
Brain CommunIlchovska ZG +5 more
europepmc +1 more source
Advanced Science, EarlyView.In this work, we show that multisensory integration in autistic children is characterized by attenuated ERP responses and α‐band desynchronization, together with reduced theta‐band communication between parieto‐occipital and frontal regions. The intermediate neural profile observed in unaffected siblings raises the possibility that altered cortical ...
Theo Vanneau +3 more
wiley +1 more source
Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning
Advanced Science, EarlyView.Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin +13 more
wiley +1 more source
Do Internalizing Syndromes have Incremental Validity for External Criteria Above and Beyond Each Other? [PDF]
Clin Psychol SciKinney KL +3 more
europepmc +1 more source
Advanced Science, EarlyView.MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov +24 more
wiley +1 more source