Results 41 to 50 of about 103,960 (266)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Stabilized Cat in a Driven Nonlinear Cavity: A Fault-Tolerant Error Syndrome Detector

Physical Review X, 2019
In quantum error correction, information is encoded in a high-dimensional system to protect it from the environment. A crucial step is to use natural, two-body operations with an ancilla to extract information about errors without causing backaction on ...
Shruti Puri, Alexander Grimm, Philippe Campagne-Ibarcq, Alec Eickbusch, Kyungjoo Noh, Gabrielle Roberts, Liang Jiang, Mazyar Mirrahimi, Michel H. Devoret, S. M. Girvin   +9 more
doaj   +1 more source

Error Correction in Dynamical Codes [PDF]

Quantum
We ask what is the general framework for a quantum error correcting code that is defined by a sequence of measurements. Recently, there has been much interest in Floquet codes and space-time codes.
Esther Xiaozhen Fu, Daniel Gottesman
doaj   +1 more source

Bladder Pain Syndrome: A Review

European Medical Journal Urology, 2020
Therapy of bladder pain syndrome (BPS) presents a significant challenge in clinical practice. Over the last 20 years, there have been important efforts directed at understanding the syndrome’s aetiology and therapeutic challenges.
Gokhan Calik, Jean de la Rosett
doaj   +1 more source

Diagnostic error: what Muir-Torre syndrome has taught us [PDF]

BMJ Case Reports, 2015
A low-grade sebaceous carcinoma was excised from a 55-year-old woman's neck. At follow-up, 11 months later, a recent diagnosis of mucinous adenocarcinoma of the colon and history of clear cell endometrial carcinoma were identified. A strong family history of bowel cancer suggested Muir-Torre syndrome.
Dmitri Wall, Caitriona Bridget Hackett, Vourneen Healy, Bart Ramsay   +3 more
openaire   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Monogenic Auto-inflammatory Syndromes: A Review of the Literature

Iranian Journal of Allergy, Asthma and Immunology, 2017
Auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive T ...
Gholamreza Azizi, Shahin Khadem Azarian, Sepideh Nazeri, Ali Mosayebian, Saleh Ghiasy, Ghazal Sadri, Ali Mohebi, Nikoo Hossein Khan Nazer, Sanaz Afraei, Abbas Mirshafiey   +9 more
doaj  

Carbohydrate-Deficient Glycoprotein Syndromes: Inborn Errors of Protein Glycosylation [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1999
The carbohydrate-deficient glycoprotein (CDG) syndromes (CDGS) are a series of autosomal recessive enzyme deficiencies which result in incomplete glycosylation of plasma proteins. CDGS types Ia and Ib have been related to deficiencies of phosphomannomutase and phosphomannose isomerase, respectively, while CDGS type II results from a deficiency of N ...
G, Keir, B G, Winchester, P, Clayton
openaire   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source