Results 221 to 230 of about 72,397 (309)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Uso de la evaluación externa de la calidad en las fases extraanalíticas de los laboratorios clínicos españoles: una encuesta de la Sociedad Española de Medicina de Laboratorio (SEQC^ML). [PDF]

Adv Lab Med
Caballero Garralda A, Comas Reixach I, García Miralles C, Gómez Rioja R, Llopis Díaz MA, Martínez Espartosa D, Nicolás de Blas R, Panadès Turró M, Puigví Fernández L, Rodelgo Jiménez L, Sufrate-Vergara B, Ventura Orriols E.   +11 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Homicides in Peru: the importance of accurate and timely recording of causes of death. [PDF]

Rev Peru Med Exp Salud Publica
Hernández-Vásquez A, Ttito-Paricahua L, Asmat-Condormango R, Quiñones-Inga J.   +3 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

[AI in primary care]. [PDF]

Aten Primaria
Rivas Sucari HC.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

[Impact of body composition and psychological state on executive functions in individuals with obesity]. [PDF]

An Sist Sanit Navar
Tomé-Fernández M, Berbegal-Bernabeu M, Sánchez-Sansegundo M, Hurtado-Sánchez JA, Tuells J, Zaragoza-Martí A.   +5 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Impact of pharmaceutical intervention on the management of insulin pens: a study in community pharmacy. [PDF]

Farm Comunitarios
Martínez Miñano J, Mañes Pérez C.
europepmc   +1 more source