Results 61 to 70 of about 7,716 (265)
The Error of Counting “Errors”
Annals of Emergency Medicine, 2008 I don’t understand why people are frightened of new ideas; I’m frightened of old ones. —John Cage There are 2 fundamentally opposed ways to look at “human errors”; we can see “error” as a cause of failures, or we can see “error” as a consequence, a symptom of problems deeper in the organization.
Department of Emergency Medicine, University of Florida, Jacksonville, FL, and Clinical Safety Research Unit, Imperial College, London, UK ( host institution ) +1 more
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Molecular Genetics and Metabolism ReportsIsolated methylmalonic acidemia (iMMA) is a group of monogenic metabolic disorders affecting methylmalonate and cobalamin metabolism. Five iMMA-responsible genes have been described to date: MMUT (MIM *609058), MMAA (MIM *607481, MMAB (MIM *607568 ...
Cynthia Fernández-Lainez +11 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Errores de escritura en español en niños de tercer grado de educación primaria
Pensamiento Psicológico, 2016 Objetivo. Describir los errores en las producciones escritas de niños de tercer grado de educación primaria de escuelas públicas, teniendo en cuenta su bajo rendimiento en pruebas del Estado. Método.
Dora Elizabeth Granados Ramos +1 more
doaj
Revista Digital Matemática, Educación e InternetLos errores y dificultades frecuentes que presentan los estudiantes de Estadística I en la UDO Anzoátegui, al aplicar técnicas de conteo, se encuentran, en su mayoría, al resolver problemas de combinación y permutación.
Manuel Vicente Centeno Romero +1 more
doaj +1 more source