Results 101 to 110 of about 83,889,227 (308)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Measurement Errors and their Propagation in the Registration of Remote Sensing Images (?) [PDF]

Reference control points (RCPs) used in establishing the regression model in the registration or geometric correction of remote sensing images are generally assumed to be ?perfect?.
Jinfeng Wang, Jianghong Ma, Yee Leung, Yong Ge   +3 more
core  

Errors-in-variables and validation problems in reaction norm predictions for wild populations [PDF]

Modeling, Identification and Control
Studies of phenotypic responses in wild populations are often based on reaction norm models where the environmental drivers in many cases are related to climate change.
Rolf Ergon
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Minimax Rates of ℓ_p-Losses for High-Dimensional Linear Errors-in-Variables Models over ℓ_q-Balls. [PDF]

Entropy (Basel), 2021
Li X, Wu D.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Practical Consequences of the Bias in the Laplace Approximation to Marginal Likelihood for Hierarchical Models

Entropy
Due to the high dimensional integration over latent variables, computing marginal likelihood and posterior distributions for the parameters of a general hierarchical model is a difficult task.
Subhash R. Lele, C. George Glen, José Miguel Ponciano   +2 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Quantile Regression with Classical Additive Measurement Errors [PDF]

This note derives the bias of the quantile regression estimator in the presence of classical additive measurement error, and show its connection to least squares models.
Gabriel Montes-Rojas
core  

Likelihood Inference in the Errors-in-Variables Model

Journal of Multivariate Analysis, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Murphy, S.A., Van Der Vaart, A.W.
openaire   +1 more source