Results 131 to 140 of about 2,032,232 (300)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Heterogeneous Income Profiles and Life-Cycle Bias in Intergenerational Mobility Estimation [PDF]
Research on intergenerational income mobility is based on current income since data on lifetime income are typically not available for two generations.
Nybom, Martin, Stuhler, Jan
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Is money informative? Evidence from a large model used for policy analysis [PDF]
In this paper we assess whether monetary variables convey marginal information on the state of the Italian economy, taking as a benchmark the forecasting errors generated by the quarterly model used by the Bank of Italy in the 1990s.
Alberto Locarno +2 more
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Prefilter design for errors in variables model identification
Proceedings of the 45th IEEE Conference on Decision and Control, 2006 The bias compensated least squares approach for errors-in-variables model identification is examined in a new framework, where it is allowed to prefilter the observed input-output data prior to the estimation process. A statistical analysis of the estimation algorithm is presented. Subsequently, it is shown how these prefilters and the weighting matrix
openaire +2 more sources
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Measurement Errors and their Propagation in the Registration of Remote Sensing Images (?) [PDF]
Reference control points (RCPs) used in establishing the regression model in the registration or geometric correction of remote sensing images are generally assumed to be ?perfect?.
Jianghong Ma +3 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Dynamic Error-in-variables Models
Austrian Journal of Statistics, 2016 Several environmental problems are described by models defined by systems of first order differential equations. Typically, the derivatives of concentrations are expressed as functions of independent variables such as temperature, pressure, pH, etc. However, the independent variables are generally known only through measurements made at discrete times.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source