Results 41 to 50 of about 8,978,880 (312)

Efficient Estimation in the Errors in Variables Model

open access: yesThe Annals of Statistics, 1987
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bickel, P. J., Ritov, Y.
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Optimality of Quasi-Score in the multivariate mean-variance model with an application to the zero-inflated Poisson model with measurement errors [PDF]

open access: yes, 2006
In a multivariate mean-variance model, the class of linear score (LS) estimators based on an unbiased linear estimating function is introduced. A special member of this class is the (extended) quasi-score (QS) estimator.
Kukush, Alexander   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Algorithms and statistical analysis for linear structured weighted total least squares problem

open access: yesGeodesy and Geodynamics
Weighted total least squares (WTLS) have been regarded as the standard tool for the errors-in-variables (EIV) model in which all the elements in the observation vector and the coefficient matrix are contaminated with random errors.
Jian Xie   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

An Effective Robust Total Least-Squares Solution Based on “Total Residuals” for Seafloor Geodetic Control Point Positioning

open access: yesRemote Sensing
Global Navigation Satellite System/Acoustic (GNSS/A) underwater positioning technology is attracting more and more attention as an important technology for building the marine Positioning, Navigation, and Timing (PNT) system.
Zhipeng Lv, Guorui Xiao
doaj   +1 more source

Least‐correlation estimates for errors‐in‐variables models [PDF]

open access: yesInternational Journal of Adaptive Control and Signal Processing, 2005
AbstractThis paper introduces an estimator for errors‐in‐variables models in which all measurements are corrupted by noise. The necessary and sufficient condition minimizing a criterion, defined by squaring the empirical correlation of residuals, yields a new identification procedure that we call least‐correlation estimator.
Jun, Byung-Eul, Bernstein, Dennis S.
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy