Results 61 to 70 of about 117,698,599 (259)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A New Approach Based on Cumulants for Estimating Financial Regression Models with Errors in the Variables: the Fama and French Model Revisited [PDF]

This paper proposes to revisit both the CAPM and the three-factor model of Fama and French (1993) in presence of errors in the variables. To reduce the bias induced by measurement and specification errors, we transpose to the cost of equity an estimator ...
Francois-Éric Racicot, Alain Coen
core  

The large deviation for the least squares estimator of nonlinear regression model based on WOD errors

Journal of Inequalities and Applications, 2016
As a kind of dependent random variables, the widely orthant dependent random variables, or WOD for short, have a very important place in dependence structures for the intricate properties.
Xufeng Huang, Xufei Tang, Xin Deng, Xuejun Wang   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Effects of errors-in-variables on the internal and external reliability measures

Geodesy and Geodynamics
The reliability theory has been an important element of the classical geodetic adjustment theory and methods in the linear Gauss-Markov model. Although errors-in-variables (EIV) models have been intensively investigated, little has been done about ...
Yanxiong Liu, Yun Shi, Peiliang Xu, Wenxian Zeng, Jingnan Liu   +4 more
doaj   +1 more source

Evaluation of the Weak Constraint Data Assimilation Approach for Estimating Turbulent Heat Fluxes at Six Sites

Remote Sensing, 2018
A number of studies have estimated turbulent heat fluxes by assimilating sequences of land surface temperature (LST) observations into the strong constraint-variational data assimilation (SC-VDA) approaches.
Xinlei He, Tongren Xu, Sayed M. Bateni, Christopher M. U. Neale, Thomas Auligne, Shaomin Liu, Kaicun Wang, Kebiao Mao, Yunjun Yao   +8 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Total least-squares EIO model, algorithms and applications

Geodesy and Geodynamics, 2019
A functional model named EIO (Errors-In-Observations) is proposed for general TLS (total least-squares) adjustment. The EIO model only considers the correction of the observation vector, but doesn't consider to correct all elements in the design matrix ...
Xingsheng Deng, Ge Liu, Tao Zhou, Sichun Peng   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Nonparametric regression for dependent data in the errors-in-variables problem [PDF]

We consider the nonparametric estimation of the regression functions for dependent data. Suppose that the covariates are observed with additive errors in the data and we employ nonparametric deconvolution kernel techniques to estimate the regression ...
Toshio Honda
core