Results 81 to 90 of about 508,417 (267)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Modified inverse propensity weighting method to alleviate estimation errors in the model with multiple endogenous variables

MethodsX
Multiple mental health disorders affect on decisions of people. The disorders are also outcomes of other factors. Health studies commonly follow an inverse propensity weight (IPW) method to address estimation errors associated with the presence of one ...
Bhubaneswor Dhakal, Geraldine. F.H. McLeod, Andrea Insch, Joseph.M. Boden   +3 more
doaj   +1 more source

Goodness-of-fit test in a multivariate errors-in-variables model $\mathit{A}\mathit{X}=\mathit{B}$

Modern Stochastics: Theory and Applications, 2016
We consider a multivariable functional errors-in-variables model $AX\approx B$, where the data matrices A and B are observed with errors, and a matrix parameter X is to be estimated.
Alexander Kukush, Yaroslav Tsaregorodtsev   +1 more
doaj   +1 more source

Influence Assessment in an Heteroscedastic Errors-in-Variables Model

Communications in Statistics - Theory and Methods, 2012
The main goal of this article is to consider influence assessment in models with error-prone observations and variances of the measurement errors changing across observations. The techniques enable to identify potential influential elements and also to quantify the effects of perturbations in these elements on some results of interest.
Galea Rojas, Manuel Jesús, Castro, Mario de   +1 more
openaire   +6 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Estimators for the errors-in-variables model

, 2018
Estimators of the parameters of the multivariate linear errors-in-variables model and the nonlinear errors-in-variables model are investigated. The multivariate linear errors-in-variables model is defined by; Y(,t) = (beta)(,0) + x(,t)(beta) + e(,t),; X(,t) = x(,t) + u(,t), t = 1,2,.,n,;where Y(,t) and X(,t) are observable random row vectors of ...
openaire   +6 more sources

In-Flight Self-Alignment Method Aided by Geomagnetism for Moving Basement of Guided Munitions

Journal of Control Science and Engineering, 2015
Due to power-after-launch mode of guided munitions of high rolling speed, initial attitude of munitions cannot be determined accurately, and this makes it difficult for navigation and control system to work effectively and validly.
Shuang-biao Zhang, Xing-cheng Li, Zhong Su   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Calibrating Car-Following Model Considering Measurement Errors

Advances in Mechanical Engineering, 2013
Car-following model has important applications in traffic and safety engineering. To enhance the accuracy of model in predicting behavior of individual driver, considerable studies strive to improve the model calibration technologies.
Chang-qiao Shao, Xiao-ming Liu, Zhi-yong Zhang   +2 more
doaj   +1 more source