Results 81 to 90 of about 2,577,886 (309)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
PharmaceuticsBackground/Objectives: Tay–Sachs disease (TSD) is a neurodegenerative disorder caused by a deficiency in β-hexosaminidase A (HexA), which accumulates GM2 gangliosides, primarily in neurons.
Jacky M. Guerrero-Vargas +6 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Clustered standard errors in Stata [PDF]
A brief survey of clustered errors, focusing on estimating cluster–robust standard errors: when and why to use the cluster option (nearly always in panel regressions), and implications.
Austin Nichols, Mark E Schaffer
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Error Analysis: A Case Study of Learner Errors in Free Compositions
, 2016 Writing is said to be the most difficult skill in English, therefore most EFL students tend to commit errors in writing. In order to help the learners to successfully acquire writing skills, it is inevitable to analyse errors and understand their sources.
Kerita, Katalin
core
Glottodidactica, 2015 Interlingual transfer is a well known phenomenon. Thanks to many psycholinguistic studies it is now known which factors can induce or hinder this kind of transfer.
Zofia Chłopek
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Errors and complications in hip arthroplasty using cement technology.
Medičnì Perspektivi, 2014 According to the latest qualitative European registers cement type of fixation of one or both components of the hip joint is used in 4,5-58 % of cases, and in Scandinavian countries the figure is close to 90%.
O. E. Loskutov, E. V. Vasil'chenko
doaj +1 more source
The Mathematical Intelligencer, 2018 It is well known that a center of a given circle cannot be constructed using only a straightedge and that this was proven by David Hilbert. Still it is not so clear what kind of object is proven to be non-existing. We analyze different attempts to define a geometric construction appearing in the literature and observe that none of them is really ...
openaire +3 more sources