Results 81 to 90 of about 2,308,308 (297)
Geomatics, Natural Hazards & Risk, 2020 A difficulty in variance component estimation (VCE) is that the estimates may become negative, which is not acceptable in practice. This article presents two new methods for non-negative VCE that utilize the expectation maximization algorithm for the ...
Leyang Wang, Qiwen Wu
doaj +1 more source
Errors-in-Variables Estimation with No Instruments [PDF]
This paper develops a wavelet (spectral) approach to estimate the parameters of a linear regression model where the regressand and the regressors are persistent processes and contain a measurement error. We propose a wavelet filtering approach which does
Nikola Gradojevic, Ramazan Gencay
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Algorithms and statistical analysis for linear structured weighted total least squares problem
Geodesy and GeodynamicsWeighted total least squares (WTLS) have been regarded as the standard tool for the errors-in-variables (EIV) model in which all the elements in the observation vector and the coefficient matrix are contaminated with random errors.
Jian Xie +4 more
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Errors-in-variables and validation problems in reaction norm predictions for wild populations [PDF]
Modeling, Identification and ControlStudies of phenotypic responses in wild populations are often based on reaction norm models where the environmental drivers in many cases are related to climate change.
Rolf Ergon
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Spatial‐statistical downscaling with uncertainty quantification in biodiversity modelling
Methods in Ecology and EvolutionAccurate downscaling with uncertainty quantification and its inclusion in fitting biodiversity models to data are essential for accurate, valid inferences and predictions.
Xiaotian Zheng +4 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Improved Errors-in-Variables Estimators for Grouped Data [PDF]
Grouping models are widely used in economics but are subject to finite sample bias. I show that the standard errors-in-variables estimator (EVE) is exactly equivalent to the Jackknife Instrumental Variables Estimator (JIVE), and use this relationship to ...
Paul J Devereux
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source