Results 61 to 70 of about 2,080 (215)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Investigation of the Adaptivity Degree of State Variables in Linear Models of Dynamic Systems

Sensors
This study investigates the concept of the adaptability degree of state variables in mathematical models used in estimation algorithms. Two numerical criteria are proposed for calculating the adaptability degree of state variables in linear models ...
Maria Selezneva, Konstantin Neusypin, Anastasia Surkova   +2 more
doaj   +1 more source

Bifactor Models for Predicting Criteria by General and Specific Factors: Problems of Nonidentifiability and Alternative Solutions

Journal of Intelligence, 2018
The bifactor model is a widely applied model to analyze general and specific abilities. Extensions of bifactor models additionally include criterion variables.
Michael Eid, Stefan Krumm, Tobias Koch, Julian Schulze   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Site-specific height-diameter and stem volume equations for Lebombo-ironwood

Annals of Forest Research, 2017
Height–diameter (H–D) and stem volume equations are indispensable tools for forest management and have a wide use in forestry, however they are lacking for Lebombo-ironwood.
Tarquinio Mateus Magalhães
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Climate model trend errors are evident in seasonal forecasts at short leads

npj Climate and Atmospheric Science
Climate models exhibit errors in their simulation of historical trends of variables including sea surface temperature, winds, and precipitation, with important implications for regional and global climate projections.
Jonathan D. Beverley, Matthew Newman, Andrew Hoell   +2 more
doaj   +1 more source

Improving dynamical climate predictions with machine learning: insights from a twin experiment framework [PDF]

Nonlinear Processes in Geophysics
Systematic errors in dynamical climate models remain a significant challenge to accurate climate predictions, particularly when modeling the nonlinear coupling between the atmosphere and ocean.
Z. He, Z. He, Z. He, J. Brajard, Y. Wang, X. Wang, X. Wang, Z. Shen, Z. Shen   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source