Results 1 to 10 of about 12,709 (160)

Back to the future: the amazing journey of the therapeutic anti-leukemia enzyme asparaginase Erwinia chrysanthemi [PDF]

Haematologica, 2023
For several decades, asparaginase has been considered world-wide as an essential component of combination chemotherapy for the treatment of childhood acute lymphoblastic leukemia (ALL).
Wing H. Tong, Carmelo Rizzari
doaj   +4 more sources

Optimizing safety and efficacy of asparaginase and blinatumomab therapy in frontline acute lymphoblastic leukemia regimens in diverse health care settings-international expert consensus. [PDF]

Cancer
ABSTRACT Frontline blinatumomab combined with chemotherapy has resulted in improved outcomes in both pediatric and adult patients with acute lymphoblastic leukemia and is considered the new cornerstone of acute lymphoblastic leukemia treatment. The role of asparaginase in this new landscape of acute lymphoblastic leukemia treatment was extensively ...
DeAngelo DJ, Avagyan A, Alfaro J, Conter V, de Martino Lee ML, Hutnik Ł, Hwang M, Inaba H, Manabe A, Park JH, Pieters R, Rizzari C, Saha V, Teachey DT, van der Sluis IM, Howard SC.   +15 more
europepmc   +2 more sources

Optimizing Asparaginase Treatment for Adolescent and Young Adult (AYA) Patients With Acute Lymphoblastic Leukemia: US Consensus Panel Recommendations. [PDF]

Am J Hematol
ABSTRACT Asparaginase is an integral component of therapy for pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma. The success of asparaginase‐containing regimens has led to trials of pediatric/pediatric‐inspired regimens incorporating asparaginase for treating adolescent and young adult (AYA) and adult populations with acute ...
Aldoss I, Ali A, Cassaday RD, Curran EK, Luskin MR, Maese LD, Orgel E, Douer D.   +7 more
europepmc   +2 more sources

Inhibition of Erwinia chrysanthemi growth to different concentrations of folic acid: possible use of folic acid as bacteriostatic agent and fortifying of Solanum tuberosum potato [PDF]

Universidad y Salud, 2017
Introduction:The enterobacteria of the Erwinia spp genus produce disease in potatoes, which is a tuber of mass consumption. The regulation of DNA methylation can regulate the proliferation of Erwinia in such a way that the concentrations of folic acid ...
Andrea Marcelo Correa, Adriana Ordóñez Vásquez, Alba Alicia Trespalacios, Fernando Suárez Obando   +3 more
doaj   +2 more sources

Colonisation of Oncidium orchid roots by the endophyte Piriformospora indica restricts Erwinia chrysanthemi infection, stimulates accumulation of NBS-LRR resistance gene transcripts and represses their targeting micro-RNAs in leaves [PDF]

BMC Plant Biology, 2019
Background Erwinia chrysanthemi (Ec) is a destructive pathogen which causes soft-rot diseases in diverse plant species including orchids. We investigated whether colonization of Oncidium roots by the endophytic fungus Piriformospora indica (Pi) restricts
Wei Ye, Jinlan Jiang, Yuling Lin, Kai-Wun Yeh, Zhongxiong Lai, Xuming Xu, Ralf Oelmüller   +6 more
doaj   +2 more sources

Successful rechallenge with Erwinia chrysanthemi asparaginase after pegaspargase-induced hypertriglyceridemia: a case report [PDF]

Therapeutic Advances in Hematology
Polyethylene-glycolated Escherichia coli -derived l -asparaginase (pegaspargase, pASP) is an essential component of paediatric-inspired regimens for the treatment of acute lymphoblastic leukaemia/lymphoma; nonetheless, is characterised by severe and ...
Gaia Ciolli, Andrea Pasquini, Francesco Mannelli, Barbara Scappini, Giacomo Gianfaldoni, Elisa Quinti, Laura Fasano, Jessica Caroprese, Francesca Crupi, Alessandro Maria Vannucchi, Matteo Piccini   +10 more
doaj   +2 more sources

Transcriptome Analysis Reveals Cross-Kingdom Virulence Factors in Erwinia persicina Cp2. [PDF]

Environ Microbiol Rep
Pathogenic mechanism of Erwinia persicina Cp2 across plant and animal kingdoms. ABSTRACT Erwinia persicina is a well‐documented plant pathogenic bacterium, causing soft rot in various plant hosts. There are rare previous reports that it is associated with animal diseases.
Huang R, Liu XN, Hsiang T, Zhang ZF.
europepmc   +2 more sources

Microorganismos asociados a la enfermedad conocida como pudrición suave del fruto de banano (musa sp.) y alternativas de control microbiológicas y químicas a nivel in vitro

Agronomía Costarricense, 2022
Introducción. La Pudrición Suave del Fruto (PSF) es una enfermedad precosecha que afecta a las musáceas. En renovación de plantaciones, las pérdidas por esta enfermedad alcanzan desde 0,3 hasta 1,2 t.ha-1.año-1 de fruta. Objetivo. Describir los síntomas
Jose Pablo Vargas Fernández, Amy Wang Wong, Miguel Muñoz Fonseca   +2 more
doaj   +1 more source

Genotypic characterisation of the Erwinia genus by PCR-RFLP analysis of rpoS gene

Plant Protection Science, 2002
Genotypic characterisation of the members of the genus Erwinia, based on the PCR-RFLP analysis of a fragment of the rpoS gene was done. PCR primers deduced from described rpoS gene sequences of E.
M. Waleron, K. Waleron, E. Łojkowska
doaj   +1 more source

L-asparaginase: New about Well-Known Drug

Педиатрическая фармакология, 2021
The history of asparaginase clinical use is inextricably linked to the improvement of treatment programs for acute lymphoblastic leukaemia (ALL). Asparaginase, obtained from E.
Yuliya S. Korkina, Timur T. Valiev
doaj   +1 more source