Results 51 to 60 of about 7,056 (213)

EGFR‐HER2 Transactivation Viewed in Space and Time Through the Versatile Spectacles of Imaging Cytometry—Implications for Targeted Therapy

Cytometry Part A, Volume 107, Issue 3, Page 187-202, March 2025.
ABSTRACT Ligand‐induced formation of signaling platforms composed of homo‐ and/or heterodimers of receptor tyrosine kinases is considered essential for their activation and consequential contribution to the progression of many cancers. Epidermal Growth Factor Receptor (EGFR) acts as a signal receiver upon EGF binding and produces mitogenic input for ...
László Ujlaky‐Nagy, János Szöllősi, György Vereb   +2 more
wiley   +1 more source

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia

Neoplasia: An International Journal for Oncology Research, 2016
Preclinical studies have suggested that the pancreatic tumor microenvironment both inhibits and promotes tumor development and growth. Here we establish the role of stromal fibroblasts during acinar-to-ductal metaplasia (ADM), an initiating event in ...
Jason R. Pitarresi, Xin Liu, Sudarshana M. Sharma, Maria C. Cuitiño, Raleigh D. Kladney, Thomas A. Mace, Sydney Donohue, Sunayana G. Nayak, Chunjing Qu, James Lee, Sarah A. Woelke, Stefan Trela, Kyle LaPak, Lianbo Yu, Joseph McElroy, Thomas J. Rosol, Reena Shakya, Thomas Ludwig, Gregory B. Lesinski, Soledad A. Fernandez, Stephen F. Konieczny, Gustavo Leone, Jinghai Wu, Michael C. Ostrowski   +23 more
doaj   +1 more source

Successful Clozapine Treatment for Treatment‐Resistant Schizophrenia With Zinc Deficiency Severe Anemia: A Case Report

Neuropsychopharmacology Reports, Volume 45, Issue 1, March 2025.
A case of severe zinc deficiency anemia after initiation of clozapine. Successful continuation of clozapine treatment with zinc supplementation. ABSTRACT Introduction Clozapine is an atypical antipsychotic drug approved for treatment‐resistant schizophrenia (TRS).
Kaoru Matsuo‐Yamamoto, Shinya Uenishi, Yuta Ishiyama, Shinichi Yamada, Yuji Kitabata, Kazuya Okamura, Sohei Kimoto   +6 more
wiley   +1 more source

The Role of Plasmapheresis in the Management of Severe Rhesus Incompatibility During Pregnancy: A Literature Review

Reproductive, Female and Child Health, Volume 4, Issue 1, March 2025.
ABSTRACT Introduction To evaluate the effectiveness and safety of plasmapheresis in cases complicated by severe alloimmunization. Methods We reviewed multiple studies from databases like Medline, Embase, and Cochrane, looking specifically for research on ‘Rhesus incompatibility’, ‘plasmapheresis’, and ‘pregnancy’.
Wael Abdallah, Assaad Kessrouani, Malek Nassar   +2 more
wiley   +1 more source

The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus

Journal of Neurochemistry, Volume 169, Issue 2, February 2025.
USP2 is a DUB involved in the circadian clock, in particular its response to light. This study shows that USP2 has a role in the response to evening light stimulation. Usp2 gene deletion did not affect retina structure or function. In contrast, deleting Usp2 specifically in the SCN, the brain location of the master clock, replicated the full‐body KO ...
Shashank B. Srikanta, Thomas W. Brown, Antoine Malescot, Marie‐Ève Cloutier, Lei Zhu, Christine Coutanson, Maryam Malki, Kai‐Florian Storch, Ravi Rungta, Michel Cayouette, Ouria Dkhissi‐Benyahya, Nicolas Cermakian   +11 more
wiley   +1 more source

Evaluation of Chlorpyriphos as an Organophosphate Pesticide on Hematology, Blood Biochemistry, Antioxidant Capacity, Oxidative Stress, and Histopathological Changes in Juvenile Silver Barb (Barbonymus gonionotus)

Aquaculture Research, Volume 2025, Issue 1, 2025.
The freshwater fish population in Bangladesh is adversely affected by the use of pesticides in agriculture. Furthermore, pesticide consumption is increasing daily due to the introduction of high‐yielding crop varieties. This study aimed to examine the impact of the organophosphate pesticide chlorpyriphos on various pathological alterations and acute ...
Zakir Hossain, Rabeya Akter, Maria Binte Moin, Shaon Kumar Mondol, Tutul Kumar Saha, Israt Jahan Tumpa, Anika Tabassum, Sadia Ibnat, Mst. Arzu Pervin, Halima Jahan, Taesun Min, Mohammad Moniruzzaman   +11 more
wiley   +1 more source

Distribution of Blood Group among Children in a Tribal Colony near Bengaluru, Karnataka, India- A Cross-sectional Study

Global Journal of Medicine and Public Health
Background ABO and Rhesus (Rh) blood groups are utilitarian tool in resolving medico legal issues, identifying, and preventing erythroblastosis fetalis and researching population genetics.
Manjula K S, Swapna Jaswanth, Reena R, Usha SMR, Latha V   +4 more
doaj   +2 more sources

Hematological Abnormalities on New-Borns et Their First Day of Extrauterine Life in Yaounde

Health Research in Africa
RÉSUMÉ Introduction. Les anomalies hématologiques chez le nouveau-né sont fréquentes et peuvent entrainer une morbidité et une mortalité importantes. Objectif.
Carolle Nsa’amang Eyebe, Gisèle Nke Ateba, Maryam Kranssa Mandari, Josiane Essola, Serge Eyebe, Magloire Biwole Sida, Dieudonné Adiogo   +6 more
doaj   +1 more source

Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells

Vaccines, 2020
The role of natural killer (NK) cells in the liver as first-line post infectionem (p.i.) effectors against blood-stage malaria and their responsiveness to protective vaccination is poorly understood.
Marcos J. Araúzo-Bravo, Denis Delic, Daniela Gerovska, Frank Wunderlich   +3 more
doaj   +1 more source

The Role of Immune System in Thalassemia Major: A Narrative Review

Journal of Pediatrics Review, 2018
Context: Thalassemia is a genetic disorder of hemoglobin production. Patients with thalassemia major (TM) require regular blood transfusions to keep a compatible hemoglobin level for oxygenating organs.  These patients suffer from different complications
Ali Bazi, Iraj Shahramian, Hajar Yaghoobi, Majid Naderi, Hakim Azizi   +4 more
doaj