Multivalent Bi-Specific Nanoerythrosomes: A Two-Birds-One-Stone Approach to Combine Homologous and Active Targeting for Effective Thrombolysis. [PDF]
SmallA multivalent bi‐specific nanoerythrosome (mBiNE@tPA) is developed as a “two‐birds‐one‐stone” platform that simultaneously exploits two principal thrombus components. By integrating erythrocyte membrane‐mediated homologous targeting with cRGD‐based active targeting to activated platelets, mBiNE@tPA achieves enhanced thrombus accumulation, triggered ...
Huang Y +10 more
europepmc +2 more sources
Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating. [PDF]
SmallPrecise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Lim JL +4 more
europepmc +2 more sources
Engineered Bacterial Membranes as Next-Generation Platforms for Cancer Immunotherapy. [PDF]
Small SciEngineered bacterial membrane platforms, including outer membrane vesicles, bacterial ghosts, genetically engineered membranes, and hybrid bacterial–tumor membranes, integrate tumor antigen presentation with intrinsic immune stimulation. These platforms promote dendritic‐cell activation, T‐cell priming, pyroptosis, and synergistic responses with ...
Malik HA +4 more
europepmc +2 more sources
Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes. [PDF]
iScienceSummary: The destruction of red blood cells by classical complement activation can form erythrocyte ghosts in immune-mediated hemolysis. However, the mechanisms involved in clearing these membrane remnants remain to be elucidated.
Wang Y +10 more
europepmc +2 more sources
Atomic force microscopy reveals involvement of the cell envelope in biomechanical properties of sickle erythrocytes. [PDF]
BMC Biol, 2023 Background Intracellular hemoglobin polymerization has been supposed to be the major determinant for the elevated rigidity/stiffness of sickle erythrocytes from sickle cell anemia (SCA) patients.
Wang K +5 more
europepmc +2 more sources
One trigger, two fates: hemolysate shapes neutrophil extracellular traps (NETs) formation in a context-dependent manner. [PDF]
Front ImmunolDuring systemic inflammation, neutrophil extracellular traps (NETs) capture pathogens but, in the long-term, can cause bystander damage to the vasculature.
Gucwa D, Such A, Kolaczkowska E.
europepmc +2 more sources
Identification of Exported Plasmodium falciparum Proteins That Bind to the Erythrocyte Cytoskeleton
Microorganisms, 2022 Plasmodium proteins are exported to the erythrocyte cytoplasm to create an environment that supports parasite replication. Although hundreds of proteins are predicted to be exported through Plasmodium export element (PEXEL)-dependent and -independent ...
Bikash Shakya +4 more
doaj +1 more source
Optimization of gradual hemolysis for isolation of hemoglobin from bovine erythrocytes [PDF]
Hemijska Industrija, 2012 In this work, we describe an optimized procedure based on gradual hemolysis for the isolation of hemoglobin derived from bovine slaughterhouse erythrocytes in a membrane bioreactor.
Pravilović Radoslava +6 more
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Erythrocyte G protein as a novel target for malarial chemotherapy. [PDF]
PLoS Medicine, 2006 Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate. Novel antimalarial drug targets are urgently needed to reduce global morbidity and mortality. Our prior results suggested
Sean C Murphy +5 more
doaj +1 more source
Journal of Extracellular Vesicles, 2023 Human blood plasma prepared by centrifugation contains not only extracellular vesicles (EVs) but also platelets and erythrocyte ghosts (ery‐ghosts).
Jillian W. P. Bracht +6 more
doaj +1 more source