Results 61 to 70 of about 693,805 (258)

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

open access: yesAdvanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo   +6 more
wiley   +1 more source

Erythrocyte voltage-dependent calcium influx is reduced in hemodialyzed patients

open access: yes, 1999
Erythrocyte voltage-dependent calcium influx is reduced in hemodialyzed patients.BackgroundUremia displays increased cytosolic free calcium ([Ca2+]i) in many different cell types, supporting the hypothesis of an altered Ca2+ transport modifying the ...
A. Caumo   +13 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

open access: yesAdvanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu   +10 more
wiley   +1 more source

Comparison of erythrocyte and reticulocyte indices for the diagnosis of iron defciency

open access: yes, 2017
Background: Te increased prevalence of iron defciency anemia represents a global public health issue which can be reduced by early diagnosis of pre-iron defcient states.
Jadranka Buturović Ponikvar   +4 more
core  

The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis: a systematic review [PDF]

open access: yes, 2015
Aims/hypothesis: The use of HbA1c for the diagnosis of diabetes is now widely advocated despite caveats to its use. Anaemia is cited as a major confounder to this use; however, the effect of erythrocyte indices and to what degree anaemia influences HbA1c
Smith, Georgina   +5 more
core   +1 more source

Seasonal Changes in Hematological Indices in Sousliks of Populations from the South of the Ukraine [PDF]

open access: yes, 1973
Seasonal dynamics of total amount of erythrocytes and leucocytes, haemoglobin concentration were investigated in Citellus pygmaeus P a 11. and C. suslicus G ii 1 d. of agrobiocenosis population in the South of the Ukraine.
Передрий, Н.С.
core   +2 more sources

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen   +10 more
wiley   +1 more source

Effect of carnosine on erythrocyte deformability in diabetic rats

open access: yes, 2012
It is known that oxidative stress plays an important role in the chronic complications of diabetes. Lipid peroxidation is one of the consequences of oxidative stress.
AYDOĞAN, Sami, Yapislar, Hande
core   +1 more source

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