Results 171 to 180 of about 22,553 (250)

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways. [PDF]

PLoS Pathog, 2018
Campino S, Marin-Menendez A, Kemp A, Cross N, Drought L, Otto TD, Benavente ED, Ravenhall M, Schwach F, Girling G, Manske M, Theron M, Gould K, Drury E, Clark TG, Kwiatkowski DP, Pance A, Rayner JC.   +17 more
europepmc   +1 more source

Serum Midkine as a Biomarker for Hepatocellular Carcinoma Treatment Response and Prognostication

Journal of Clinical Laboratory Analysis, EarlyView.
Up‐to‐date, tumor markers are considered more helpful in the evaluation of treatment response and prognostication rather than diagnosis. Identifying a valid biomarker to help clinical management of hepatocellular carcinoma (HCC) is still a challenge, especially the alpha‐fetoprotein (AFP) negative HCC. This study evaluated the efficacy of serum Midkine
Yanfang Luo, Qiuwei Lu, Jing Huang, Liejun Jiang   +3 more
wiley   +1 more source

Utility of a Combined Diagnostic and Severity Scoring System Based on Complete Blood Count and Derived Immune‐Inflammatory Indicators in Children With Mycoplasma pneumoniae Pneumonia

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a simple, low‐cost scoring system using routine complete blood count (CBC) and derived immune‐inflammatory indicators (LYM%, PLT, PCT, and PLT × LYM) for early diagnosis of Mycoplasma pneumoniae pneumonia (MPP) in 1662 children. Age‐stratified analysis confirmed that key indicators remained significantly higher in the pneumonia ...
Quan Liu, Li Wei, Liang Wang, Xing‐Mei Zhu, Hai‐Feng Wang, Ling Ge   +5 more
wiley   +1 more source

Plasmodium falciparum erythrocyte invasion: combining function with immune evasion. [PDF]

PLoS Pathog, 2014
Wright GJ, Rayner JC.
europepmc   +1 more source

Biomarkers of Endothelial Damage in Acute Graft‐Versus‐Host Disease After Allogenic Hematopoietic Stem Cell Transplantation: Methodological Challenges

Journal of Clinical Laboratory Analysis, EarlyView.
Allogeneic hematopoietic stem cell transplantation remains a potentially curative therapy for many hematological malignancies; however, its success is significantly limited by acute graft‐versus‐host disease (aGVHD), a leading cause of post‐transplant morbidity and mortality in which endothelial dysfunction plays a central role.
Katarina Klinar, Helena Podgornik
wiley   +1 more source

Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum.

Blood, 2018
Zhang MY, Zhang Y, Wu XD, Zhang K, Lin P, Bian HJ, Qin MM, Huang W, Wei D, Zhang Z, Wu J, Chen R, Feng F, Wang B, Nan G, Zhu P, Chen ZN.   +16 more
europepmc   +1 more source

Elevated Hemoglobin A2: A Molecular Revisited, and Implications to β‐Thalassemia Screening

Journal of Clinical Laboratory Analysis, EarlyView.
In Thailand, the Hb A2 cut‐off value for β‐thalassemia carrier has been changed from 4.0% to 3.6% since 2015. We examined the molecular basis of β‐thalassemia in a large cohort of Thai subjects with this change. The molecular basis of β‐thalassemia was updated, and a change in the Hb A2 cut‐off can alter this spectrum.
Kritsada Singha, Anupong Pansuwan, Hataichanok Srivorakun, Attawut Chaibunruang, Supawadee Yamsri, Wanicha Tepakhan, Kanokwan Sanchaisuriya, Goonnapa Fucharoen, Supan Fucharoen   +8 more
wiley   +1 more source

In silico analysis of the invasion mechanics and invasiveness of the Plasmodium falciparum merozoite. [PDF]

Biomech Model Mechanobiol
Msosa C, Abdalrahman T, Franz T.
europepmc   +1 more source

A New Diagnostic Approach Using the NLR/LMR Ratio in the Differential Diagnosis of Neck Masses: Hematologic Evaluation of Patients With Cervical Lymphadenopathy

Journal of Clinical Laboratory Analysis, EarlyView.
This study evaluates complete blood count–derived inflammatory ratios for differentiating lymphoma from benign cervical lymphadenopathies. The novel NLR/LMR ratio demonstrated superior diagnostic performance (AUC = 0.71, OR = 4.6) compared with conventional indices.
Servet Erdemes, Gizem Ay Haldız, Müslüm Ayral, Ali Çetin   +3 more
wiley   +1 more source